ADHFE1: Key Enzyme in Alcohol Metabolism and Potential Drug Target

Target Name: ADHFE1

NCBI ID: G137872

ADHFE1

ADHFE1: Key Enzyme in Alcohol Metabolism and Potential Drug Target

Alcohol dehydrogenase iron containing 1 (ADHFE1) is a protein that is expressed in various tissues throughout the body, including the liver, heart, and kidneys. It is a key enzyme in the metabolism of alcohol, which is involved in the production of toxic compounds that can harm the body.

ADHFE1 is a member of the superfamily of cytoskeletal proteins known as the Myb protein family. It consists of four structurally similar subunits that are held together by disulfide bonds. The subunits contain a variable region that includes a conserved catalytic core and several distinct regions that are involved in the interactions with other molecules.

One of the unique features of ADHFE1 is its ability to catalyze the production of toxic compounds from alcohol, such as hydraxyacetone (HAA) and 2-acetyl-1-propanone (2-propanone). These compounds are highly toxic and can cause damage to various tissues and organs, including the liver, heart, and kidneys.

The role of ADHFE1 in the metabolism of alcohol is well established in the scientific literature. Studies have shown that ADHFE1 is involved in the production of these toxic compounds from alcohol, and that its activity is regulated by various chemical and biological factors.

One of the potential drug targets for ADHFE1 is the inhibition of its activity, as this could lead to a reduction in the production of toxic compounds from alcohol. This is an attractive idea because many of the harmful effects of alcohol are associated with the production of these compounds, and could be addressed by drugs that specifically target ADHFE1.

Another potential drug target for ADHFE1 is the modulation of its expression. Many diseases are associated with changes in the levels of various proteins, including ADHFE1, and these changes can have a significant impact on the health and wellbeing of the individual. By targeting ADHFE1 with drugs that either enhance or inhibit its expression, researchers may be able to improve the health outcomes of individuals with these diseases.

In addition to its potential as a drug target, ADHFE1 is also a potential biomarker for a variety of diseases. The production of toxic compounds from alcohol is a well-established indicator of liver damage, and individuals with liver damage may have increased levels of ADHFE1 in their bloodstream. Similarly, the inhibition of ADHFE1 activity has been shown to protect liver tissue from damage in various models of liver disease.

Overall, ADHFE1 is a protein that is involved in the metabolism of alcohol and is potential drug and biomarker target. Further research is needed to fully understand its role in the development and progression of various diseases, and to develop effective treatments that target its activity.

Protein Name: Alcohol Dehydrogenase Iron Containing 1

Functions: Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). D,L-3-hydroxyisobutyrate and L-3-hydroxybutyrate (L-3-OHB) are also substrates for HOT with 10-fold lower activities

The "ADHFE1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ADHFE1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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