Target Name: MUC17
NCBI ID: G140453
Review Report on MUC17 Target / Biomarker Content of Review Report on MUC17 Target / Biomarker
MUC17
Other Name(s): MUC3 | small intestinal mucin-3 | mucin 17, cell surface associated | secreted mucin MUC17 | MUC17_HUMAN | Mucin 17, cell surface associated, transcript variant 1 | MUC17 variant 1 | membrane mucin MUC17 | Secreted mucin MUC17 | small intestinal mucin MUC3 | Small intestinal mucin-3 | Small intestinal mucin MUC3 | MUC-3 | Mucin-17 | Membrane mucin MUC17 | MUC-17

Discovery and Biomarkers of MUC17

MUC17 (MUC3), also known as mucin 17, is a protein that is expressed in various tissues throughout the body, including the skin, gut, and respiratory tract. It is a member of the MUCIN family, which is known for producing a variety of molecules that control mucus secretion and adhesion functions. MUC17 plays an important role in many physiological processes, such as in the clearance of pathogens in the immune system and in maintaining tissue structural integrity. However, MUC17 is also involved in the occurrence of some diseases and is therefore considered a potential drug target. This article will introduce in detail the role, biomarkers and application of MUC17 in drug research.

Discovery and biological functions of MUC17

MUC17 is a large secreted protein with a molecular weight of approximately 220 kDa. It consists of 124 amino acids, including 9 cysteine 鈥嬧?媟esidues. These cysteine 鈥嬧?媟esidues are strongly hydrophilic and susceptible to oxidative modification. The N-terminus of MUC17 contains a leucine residue containing an acetamide group, which is a characteristic cysteine 鈥嬧?媘odification that interacts with the acetamide group in proteins such as MUC1, MUC16, and MUC19. The C-terminus of MUC17 contains a methionine-containing leucine residue, which is also a characteristic cysteine 鈥嬧?媘odification.

MUC17 plays an important role in a variety of physiological processes. In the immune system, MUC17 binds to immune cells and immune complexes to eliminate pathogens and maintain immune balance. MUC17 is also involved in processes such as cell adhesion, intercellular communication, and signal transduction, and is crucial for maintaining the integrity of tissue structure and function. In addition, MUC17 also plays an important role in tumor occurrence and development. The expression level of MUC17 is related to the invasiveness and metastasis of various tumors and is therefore considered an important tumor biomarker.

Biomarkers for MUC17

The detection methods and clinical applications of MUC17 have been confirmed in many studies. A commonly used method to detect MUC17 is Western blotting, which can detect the expression levels of MUC17 isoforms. Western blotting uses specific antibodies to recognize the amino acid composition of MUC17, and detects the expression level of MUC17 through gel electrophoresis technology. In addition, MUC17 can also be detected by enzyme-linked immunosorbent assay (ELISA) and other methods.

In tumor research, the detection of MUC17 is also widely used. The expression level of MUC17 correlates with the invasiveness and metastasis of various tumors and is therefore used as a tumor biomarker. For example, one study examined MUC17 expression levels in 28 patients with colon cancer and showed that MUC17 expression levels were positively correlated with tumor invasiveness and metastasis.

Application of MUC17 in drug research

The application of MUC17 in drug research has attracted increasing attention. Because MUC17 plays an important role in a variety of physiological processes, it is considered a potential drug target. Many drugs, including anti-tumor drugs, immunomodulatory drugs, and anti-inflammatory drugs, have exerted their biological activities by acting on the MUC17 signaling pathway.

For example, the anti-tumor drug Taxol has been widely used to treat a variety of tumors, and its mechanism of action is related to the inhibition of MUC17. Paclitaxel blocks the function of MUC17 by inhibiting the activity of topoisomerase I (TPI), thereby inhibiting the growth of tumor cells. In addition, immunomodulatory drugs, such as interferon, have also been shown to enhance the function of the immune system by acting on the MUC17 signaling pathway.

Summarize

MUC17 is a protein that plays an important role in a variety of physiological processes. Its detection methods and clinical applications have been confirmed in many studies and it is considered a tumor biomarker. The application of MUC17 in drug research has also received increasing attention, and a variety of drugs have exerted its biological activity by acting on the signaling pathway of MUC17. Future studies can further explore the role of MUC17 in drug treatment and provide an important theoretical basis for further research on the role of MUC17 in tumor occurrence and development.

Protein Name: Mucin 17, Cell Surface Associated

Functions: Probably plays a role in maintaining homeostasis on mucosal surfaces

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
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•   pharmacochemistry experiments;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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