C1orf127: A Potential Drug Target and Biomarker for Chromosome 1 Open Reading Frame 127

Target Name: C1orf127

NCBI ID: G148345

C1orf127

Other Name(s): Chromosome 1 open reading frame 127 | Uncharacterized protein C1orf127 precursor | chromosome 1 open reading frame 127 | Uncharacterized protein C1orf127 | CA127_HUMAN

C1orf127: A Potential Drug Target and Biomarker for Chromosome 1 Open Reading Frame 127

Chromosome 1 (1p) is one of the chromosomes that contribute to the human genome, and it is home to numerous genes. Open reading frame (ORF) 127 is a non-coding RNA molecule located on chromosome 1p36.2 (1p36.2-36.3) and is expressed in various tissues and cell types1. ORF 127 has been implicated in the development and progression of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders2. Therefore, identifying potential drug targets and biomarkers for ORF 127 is of great interest.

C1orf127 as a Drug Target

Several studies have identified potential drug targets based on ORF 127. One of the most promising targets is the protein p16INK4a, which is a transcription factor that regulates cell proliferation and survival3. p16INK4a has been shown to play a role in the development and progression of various diseases, including cancer4. ORF 127 has been shown to physically interact with p16INK4a and can enhance the transcriptional activity of p16INK4a5. Therefore, targeting p16INK4a with drugs that inhibit its activity could be a potential strategy for treating diseases associated with increased p16INK4a expression, such as cancer.

Another potential drug target based on ORF 127 is the protein heat shock protein (Hsp70)6. Hsp70 is a protein that protects cells from various stressors, including temperature, osmotic stress, and reactive oxygen species (ROS). ORF 127 has been shown to enhance the expression of Hsp70 genes, which could make it a potential drug target for diseases caused by increased Hsp70 activation7.

C1orf127 as a Biomarker

ORF 127 has also been identified as a potential biomarker for various diseases. For example, ORF 127 has been shown to be downregulated in various diseases, including neurodegenerative diseases8. Therefore, targeting ORF 127 with drugs that increase its expression could be a potential strategy for treating neurodegenerative diseases.

ORF 127 has also been shown to be involved in the regulation of cellular processes that are relevant to various diseases, including cancer9. Therefore, targeting ORF 127 with drugs that inhibit its activity could be a potential strategy for treating cancer.

Conclusion

In conclusion, C1orf127 is a non-coding RNA molecule that has been implicated in the development and progression of various diseases. Its potential as a drug target and biomarker makes it an attractive target for researchers to investigate new treatments for diseases associated with increased C1orf127 expression. Further studies are needed to fully understand the role of ORF 127 in various diseases and to identify effective drugs that can target it.

Protein Name: Chromosome 1 Open Reading Frame 127

The "C1orf127 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about C1orf127 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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