PPP4R2: A Protein At The Center of Protein Homeostasis and Disease

Target Name: PPP4R2

NCBI ID: G151987

PPP4R2

PPP4R2: A Protein At The Center of Protein Homeostasis and Disease

PPP4R2 (Proteasome-associated protein 4R2) is a protein that is expressed in various tissues and cells in the human body. It plays a crucial role in the regulation of protein homeostasis, which is the process by which the body removes damaged or unnecessary proteins from its cells. PPP4R2 is a key player in this process and has been implicated in a number of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

Despite the significant impact of PPP4R2 on human health, its precise function and the mechanisms by which it interacts with other proteins are not well understood. This lack of understanding has hindered the development of new treatments for these diseases. However, recent research has identified potential drug targets and biomarkers for PPP4R2, which may provide valuable insights into its role in human disease.

In this article, we will explore the biology and implications of PPP4R2, with a focus on its potential as a drug target and biomarker. We will discuss the current state of research on PPP4R2, including its expression and function in various tissues, its involvement in disease, and the potential for new treatments.

Expression and Function

PPP4R2 is a member of theProteasome-associated protein (PAP) family, which includes a variety of structurally similar proteins that play important roles in protein homeostasis. These proteins are involved in the regulation of protein import and export, as well as the degradation of damaged proteins.

PPP4R2 is predominantly expressed in the brain, where it is involved in the regulation of synaptic plasticity, the ability of the brain to change and adapt over time. It is also expressed in other tissues, including the lungs, heart, and kidneys. PPP4R2 has been shown to play a role in the regulation of neurotransmitter release and synaptic plasticity, as well as in the modulation of pain perception.

In addition to its role in protein homeostasis, PPP4R2 is also involved in the regulation of cellular processes that are critical for survival. For example, it has been shown to play a role in the regulation of cell death, as well as in the regulation of cell cycle progression.

Disease and Potential Therapies

The lack of effective treatments for certain diseases has led to a significant focus on the development of new therapies that target PPP4R2 and its downstream targets. This focus is driven by the belief that targeting PPP4R2 and its associated proteins may provide new avenues for the development of effective treatments for a variety of diseases.

One potential approach to treating PPP4R2-related diseases is the use of small molecules that can modulate the activity of PPP4R2. For example, a number of small molecules have been shown to inhibit the activity of PPP4R2, including those that are currently being evaluated as potential drugs for a variety of diseases.

In addition to small molecules, researchers are also exploring the use of antibodies that can specifically target PPP4R2 and its associated proteins. These antibodies have the potential to selectively target the abnormal proteins that are produced in diseases caused by the activity of PPP4R2, and may provide a more targeted and effective treatment approach.

Conclusion

PPP4R2 is a protein that is involved in the regulation of protein homeostasis and has been implicated in a number of diseases. Despite the significant impact of PPP4R2 on human health, its precise function and the mechanisms by which it interacts with other proteins are not well understood. The development of new treatments for PPP4R2-related diseases is an active area of research, with a focus on the use of small molecules and antibodies to modulate the activity of PPP4R2.

Protein Name: Protein Phosphatase 4 Regulatory Subunit 2

Functions: Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair

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