DDX11: A Drug Target / Disease Biomarker (G1663)

Target Name: DDX11

NCBI ID: G1663

DDX11

DDX11: A Drug Target / Disease Biomarker

DDX11 is a drug target and a biomarker that is being studied for its potential utility in treating various diseases, including cancer. It is a protein that is expressed in various tissues and organs, including the brain, and has been shown to play a role in a number of cellular processes.

One of the things that makes DDX11 an interesting drug target is its unique structure. DDX11 is a transmembrane protein, which means that it spans the cell membrane and extends into the cytoplasm. This allows it to interact with a wide range of molecules on the cell surface, making it a potentially versatile drug target.

In addition to its unique structure, DDX11 has also been shown to play a role in a number of important cellular processes. For example, it has been shown to be involved in the regulation of cell adhesion, which is the process by which cells stick together and form tissues. This is important for many different types of cancer, as cancer cells often have a tendency to form tumors and spread to other parts of the body.

Another important function of DDX11 is its role in the regulation of the blood-brain barrier. This is the barrier that separates the brain from the rest of the body and helps to protect it from harmful substances. By regulating the blood-brain barrier, DDX11 may have the potential to treat a wide range of neurological disorders, including Alzheimer's disease and Parkinson's disease.

In addition to its potential use in treating neurological disorders, DDX11 may also be a useful biomarker for certain types of cancer. For example, it has been shown to be upregulated in a number of different types of cancer, which may make it a useful target for drugs that are designed to inhibit its activity.

The study of DDX11 is still in its early stages, but it is an exciting area of research because of its potential to treat a wide range of diseases. As more research is done onDDX11, it is likely to be found to have even more uses and applications.

Protein Name: DEAD/H-box Helicase 11

Functions: DNA-dependent ATPase and ATP-dependent DNA helicase that participates in various functions in genomic stability, including DNA replication, DNA repair and heterochromatin organization as well as in ribosomal RNA synthesis (PubMed:10648783, PubMed:21854770, PubMed:23797032, PubMed:26089203, PubMed:26503245). Its double-stranded DNA helicase activity requires either a minimal 5'-single-stranded tail length of approximately 15 nt (flap substrates) or 10 nt length single-stranded gapped DNA substrates of a partial duplex DNA structure for helicase loading and translocation along DNA in a 5' to 3' direction (PubMed:18499658, PubMed:22102414). The helicase activity is capable of displacing duplex regions up to 100 bp, which can be extended up to 500 bp by the replication protein A (RPA) or the cohesion CTF18-replication factor C (Ctf18-RFC) complex activities (PubMed:18499658). Shows also ATPase- and helicase activities on substrates that mimic key DNA intermediates of replication, repair and homologous recombination reactions, including forked duplex, anti-parallel G-quadruplex and three-stranded D-loop DNA molecules (PubMed:22102414, PubMed:26503245). Plays a role in DNA double-strand break (DSB) repair at the DNA replication fork during DNA replication recovery from DNA damage (PubMed:23797032). Recruited with TIMELESS factor upon DNA-replication stress response at DNA replication fork to preserve replication fork progression, and hence ensure DNA replication fidelity (PubMed:26503245). Cooperates also with TIMELESS factor during DNA replication to regulate proper sister chromatid cohesion and mitotic chromosome segregation (PubMed:17105772, PubMed:18499658, PubMed:20124417, PubMed:23116066, PubMed:23797032). Stimulates 5'-single-stranded DNA flap endonuclease activity of FEN1 in an ATP- and helicase-independent manner; and hence it may contribute in Okazaki fragment processing at DNA replication fork during lagging strand DNA synthesis (PubMed:18499658). Its ability to function at DNA replication fork is modulated by its binding to long non-coding RNA (lncRNA) cohesion regulator non-coding RNA DDX11-AS1/CONCR, which is able to increase both DDX11 ATPase activity and binding to DNA replicating regions (PubMed:27477908). Also plays a role in heterochromatin organization (PubMed:21854770). Involved in rRNA transcription activation through binding to active hypomethylated rDNA gene loci by recruiting UBTF and the RNA polymerase Pol I transcriptional machinery (PubMed:26089203). Plays a role in embryonic development and prevention of aneuploidy (By similarity). Involved in melanoma cell proliferation and survival (PubMed:23116066). Associates with chromatin at DNA replication fork regions (PubMed:27477908). Binds to single- and double-stranded DNAs (PubMed:9013641, PubMed:18499658, PubMed:22102414)

The "DDX11 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about DDX11 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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