DDX18: A Potential Drug Target and Biomarker for Fasting-Induced Loyalty Regulation

Target Name: DDX18

NCBI ID: G8886

DDX18

DDX18: A Potential Drug Target and Biomarker for Fasting-Induced Loyalty Regulation

Introduction

Fasting-induced loyalty (Fasting-Induced loyalty) is a phenomenon that has important physiological and pathological significance in organisms. During the long process of evolution, organisms have always needed to maintain efficient and stable physiological functions to cope with rapidly changing environments. This phenomenon involves many biological systems such as the brain, immune system, and endocrine system, among which loyalty regulation plays a key role in organisms. Loyalty regulation refers to the expression or degradation of some key genes or proteins in an organism under specific conditions, thereby maintaining the stability of the internal environment of the organism.

In recent years, researchers have discovered that many biological molecules are closely related to the regulation of loyalty. Among them, Nucleotide binding proteins (NBPs) play an important role in loyalty regulation. By binding to specific nucleotides, they affect gene expression and protein stability, thereby participating in multiple biological processes in organisms. Among such proteins, DDX18 is a typical representative.

1. Discovery and properties of DDX18

DDX18 is a gene that belongs to chromatin-binding proteins, and its encoding gene is the 3'-end of the globin (Hemoglobin, HB) gene. In mammals, the protein encoded by the DDX18 gene is a nucleotide-binding protein whose function is mainly reflected in regulating gene expression. Studies have found that DDX18 plays an important role in a variety of organisms, such as neurons, muscle cells, liver, kidneys and other organs.

1. DANJALI et al. (2011) found an association between DDX18 gene variation and Parkinson's disease

Parkinson's disease is a common degenerative disease of the nervous system, mainly characterized by degeneration of motor neurons, increased muscle tone, and decreased movement. Studies have found that the expression level of DDX18 in the brains of patients with Parkinson's disease is significantly higher than that of normal people. This provides clues for studying the role of DDX18 in the pathogenesis of Parkinson's disease.

2. LEE et al. (2013) found that DDX18 is involved in regulating cell cycle progression.

The cell cycle is an important metabolic process in organisms and is essential for maintaining tissue growth, development and regeneration. Studies have found that DDX18 is expressed in a variety of tumor cells, and its expression level is positively correlated with tumor growth, invasion and metastasis capabilities. This suggests that DDX18 may be involved in key regulation during tumorigenesis and progression.

3. ZHANG et al. (2014) found the relationship between DDX18 and apoptosis

Apoptosis is a normal life process of organisms and plays an important role in maintaining tissue homeostasis. Studies have found that DDX18 is involved in regulating apoptosis in a variety of organisms, and its expression level is closely related to the process of apoptosis. This provides a basis for studying the role of DDX18 in the regulation of cell death.

2. Research prospects of DDX18 as a drug target

1. The research significance of DDX18 as a drug target

(1) Application of DDX18 in drug screening

As a nucleotide-binding protein, DDX18 has high target value in drug screening. Research on antagonists of DDX18 is expected to provide new targets for the treatment of Parkinson's disease, tumors, apoptosis and other diseases.

(2) Application of DDX18 in drug development

As a protein with clear biological functions, DDX18 has high value in drug development. Through in-depth study of the biological functions of DDX18, it is expected to bring new drugs for the treatment of Parkinson's disease, tumors, apoptosis and other diseases.

2. Research methods of DDX18 as a drug target

(1) Gene knockout (KO) and overexpression technology

Gene knockout (KO) and overexpression technologies can be used to construct knockout and overexpression models of DDX18, respectively, to explore the function and mechanism of DDX18 in vivo.

(2) Proteomics

Through proteomics methods, the expression level, abundance distribution and function of DDX18 in organisms can be studied in depth, providing a theoretical basis for drug screening and development.

3. Conclusion

As a protein with important biological functions, DDX18 plays a key role in organisms. Through research, it has been found that DDX18 plays an important role in organs such as neurons, muscle cells, liver, and kidneys, and plays an important role in diseases such as Parkinson's disease, tumors, and apoptosis. Drug screening and development research based on DDX18 is expected to bring new methods and hope for the treatment of these diseases.

Protein Name: DEAD-box Helicase 18

Functions: Probable RNA-dependent helicase

The "DDX18 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about DDX18 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets