DHX36: A Drug Target / Disease Biomarker (G170506)

Target Name: DHX36

NCBI ID: G170506

DHX36

DHX36: A Drug Target / Disease Biomarker

DHX36 is a protein that is expressed in various tissues throughout the body. It is a member of the homeobox gene family, which is a family of genes that are involved in the development and maintenance of tissues and organs. DHX36 is also known as XBP2, and it is localized to the nuclei of various tissues in the body.

One of the key functions of DHX36 is its role in the regulation of gene expression. It is a transcription factor that can bind to specific DNA sequences and regulate the expression of genes that are associated with those sequences. This function is critical for the development and maintenance of tissues and organs, as well as for the regulation of various cellular processes that are essential for life.

In addition to its role in gene expression, DHX36 is also involved in the regulation of DNA replication. It is a critical factor in the replication of DNA in the nucleus of eukaryotic cells, and it is involved in the regulation of the timing and progression of DNA replication.

DHX36 is also involved in the regulation of various cellular processes that are essential for the development and maintenance of tissues and organs. It is a key factor in the development of the nervous system, and it is involved in the regulation of neural cell proliferation and differentiation. It is also involved in the regulation of the development and maintenance of the endocrine system, and it is a key factor in the regulation of hormone secretion.

In addition to its role in the regulation of cellular processes, DHX36 is also involved in the development and maintenance of tissues and organs. It is a key factor in the development of the placenta, and it is involved in the regulation of placenta-tissue interactions. It is also involved in the regulation of the development and maintenance of various tissues and organs in the body, including the liver, heart, and kidneys.

DHX36 is also involved in the regulation of the development and maintenance of the immune system. It is a key factor in the development of T cells, and it is involved in the regulation of the immune response. It is also involved in the regulation of the development and maintenance of the gut microbiome, and it is a key factor in the regulation of the immune response in the gut.

In conclusion, DHX36 is a protein that is involved in a wide range of cellular processes that are essential for the development and maintenance of tissues and organs. It is a key factor in the regulation of gene expression, DNA replication, and cellular processes that are essential for the development and maintenance of tissues and organs. It is also involved in the development and maintenance of the nervous system, the endocrine system, and the immune system. Therefore, DHX36 is a potential drug target and a biomarker for various diseases.

Protein Name: DEAH-box Helicase 36

Functions: Multifunctional ATP-dependent helicase that unwinds G-quadruplex (G4) structures (PubMed:16150737, PubMed:18854321, PubMed:20472641, PubMed:21586581). Plays a role in many biological processes such as genomic integrity, gene expression regulations and as a sensor to initiate antiviral responses (PubMed:14731398, PubMed:18279852, PubMed:21993297, PubMed:22238380, PubMed:25579584). G4 structures correspond to helical structures containing guanine tetrads (By similarity). Binds with high affinity to and unwinds G4 structures that are formed in nucleic acids (G4-ADN and G4-RNA) (PubMed:16150737, PubMed:18842585, PubMed:20472641, PubMed:21586581, PubMed:24369427, PubMed:26195789). Plays a role in genomic integrity (PubMed:22238380). Converts the G4-RNA structure present in telomerase RNA template component (TREC) into a double-stranded RNA to promote P1 helix formation that acts as a template boundary ensuring accurate reverse transcription (PubMed:20472641, PubMed:21149580, PubMed:21846770, PubMed:22238380, PubMed:24151078, PubMed:25579584). Plays a role in transcriptional regulation (PubMed:21586581, PubMed:21993297). Resolves G4-DNA structures in promoters of genes, such as YY1, KIT/c-kit and ALPL and positively regulates their expression (PubMed:21993297). Plays a role in post-transcriptional regulation (PubMed:27940037). Unwinds a G4-RNA structure located in the 3'-UTR polyadenylation site of the pre-mRNA TP53 and stimulates TP53 pre-mRNA 3'-end processing in response to ultraviolet (UV)-induced DNA damage (PubMed:27940037). Binds to the precursor-microRNA-134 (pre-miR-134) terminal loop and regulates its transport into the synapto-dendritic compartment (By similarity). Involved in the pre-miR-134-dependent inhibition of target gene expression and the control of dendritic spine size (By similarity). Plays a role in the regulation of cytoplasmic mRNA translation and mRNA stability (PubMed:24369427, PubMed:26489465). Binds to both G4-RNA structures and alternative non-quadruplex-forming sequence within the 3'-UTR of the PITX1 mRNA regulating negatively PITX1 protein expression (PubMed:24369427). Binds to both G4-RNA structure in the 5'-UTR and AU-rich elements (AREs) localized in the 3'-UTR of NKX2-5 mRNA to either stimulate protein translation or induce mRNA decay in an ELAVL1-dependent manner, respectively (PubMed:26489465). Binds also to ARE sequences present in several mRNAs mediating exosome-mediated 3'-5' mRNA degradation (PubMed:14731398, PubMed:18279852). Involved in cytoplasmic urokinase-type plasminogen activator (uPA) mRNA decay (PubMed:14731398). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). Required for early embryonic development and hematopoiesis. Involved in the regulation of cardioblast differentiation and proliferation during heart development. Involved in spermatogonia differentiation. May play a role in ossification (By similarity)

The "DHX36 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about DHX36 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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