CYP4Z1: A Drug Target / Disease Biomarker (G199974)

Target Name: CYP4Z1

NCBI ID: G199974

CYP4Z1

CYP4Z1: A Drug Target / Disease Biomarker

CYP4Z1 is a gene that encodes a protein known as CYP4Z1A. This gene is located on chromosome 12 and is responsible for the production of the CYP4Z1 protein. CYP4Z1A is a member of the CYP4 family, which is known for its role in the synthesis of a variety of compounds, including drugs, toxins, and environmental pollutants.

CYP4Z1A is a 21-kDa protein that is expressed in a variety of tissues and cells throughout the body. It is primarily localized to the cytoplasm of cells and is also found in the endoplasmic reticulum (ER) and the mitochondria. CYP4Z1A is involved in a number of cellular processes, including metabolism, inflammation, and stress response.

One of the most significant functions of CYP4Z1A is its role in the detoxification of xenobiotics, such as drugs and environmental toxins. Xenobiotics are substances that are not naturally occurring in the body but are introduced into the body through various means, such as ingestion, inhalation, or exposure to environmental pollution. Many of these substances are harmful to the body and can cause chronic diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases.

CYP4Z1A plays a key role in the detoxification of xenobiotics by participating in the detoxification pathway. This pathway involves the transfer of xenobiotics from the xenobiotics to the cytoplasm and the subsequent delivery to the endoplasmic reticulum for elimination. CYP4Z1A is a key player in this process, as it is responsible for the transfer of xenobiotics from the cytoplasm to the ER.

In addition to its role in detoxification, CYP4Z1A is also involved in the regulation of cellular processes that are critical for proper cell function. For example, CYP4Z1A is involved in the metabolism of nutrients, such as glucose and fatty acids, and in the regulation of cellular signaling pathways that are involved in cell growth, differentiation, and stress response.

CYP4Z1A is also involved in the regulation of inflammation. Many diseases, including cancer, are caused by chronic inflammation. CYP4Z1A is involved in the regulation of the inflammatory response by participating in the production of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1).

CYP4Z1A is also involved in the regulation of stress response. Stress can have a negative impact on cellular function and contribute to the development of many diseases, including cardiovascular diseases and neurodegenerative diseases. CYP4Z1A is involved in the regulation of the stress response by participating in the production of stress hormones, such as cortisol and adrenaline.

Despite its many important functions, CYP4Z1A is not without its problems. One of the most significant challenges associated with this gene is its role in the development of cancer. Many studies have suggested that CYP4Z1A is involved in the development and progression of many types of cancer, including breast, ovarian, and prostate cancers. In addition, CYP4Z1A has also been implicated in the development of neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases.

Despite these challenges, CYP4Z1A is still an important gene that is involved in a wide range of cellular processes. Its role in the detoxification of xenobiotics, regulation of cell

Protein Name: Cytochrome P450 Family 4 Subfamily Z Member 1

Functions: A cytochrome P450 monooxygenase that catalyzes the in-chain oxidation of fatty acids (PubMed:19090726, PubMed:29018033). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates lauric and myristic acids predominantly at the omega-4 and omega-2 positions, respectively (PubMed:19090726, PubMed:29018033). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA). Displays an absolute stereoselectivity in the epoxidation of arachidonic acid producing the 14(S),15(R)-epoxyeicosatrienoic acid (EET) enantiomer (PubMed:29018033). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:19090726, PubMed:29018033)

The "CYP4Z1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CYP4Z1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets