CBAS3: A Drug Target and Key Player in Drug Metabolism (G9420)

Target Name: CYP7B1

NCBI ID: G9420

CYP7B1

CBAS3: A Drug Target and Key Player in Drug Metabolism

CYP7B1, also known as CBAS3, is a gene that encodes for the beyond enzyme 7B1 (CYP7B1) protein. This protein is a key player in the metabolism of many drugs, including many statins, antidepressants, and benzodiazepines. Because of its role in drug metabolism Due to its important role, CBAS3 has become a research hotspot in many drug research and development fields.

Variants of the CBAS3 gene are common in humans and other organisms. Its variants can lead to changes in protein structure or function, thereby affecting drug metabolism. Many studies have shown that CBAS3 variants are associated with abnormal drug metabolism and drug resistance.

Currently, CBAS3 has been widely studied as a drug target (or biomarker). Over the past few years, researchers have discovered a number of drug targets related to CBAS3. These drug targets include CBAS3 itself, molecules related to CBAS3 and drug metabolism, and genes regulated by CBAS3.

Among them, molecules related to CBAS3 and drug metabolism refer to some molecules that interact with CBAS3 and affect its function. These molecules include drug-metabolizing enzymes, substrate-binding proteins, transporters, etc. Studies have shown that the interaction of these molecules with CBAS3 is an important link in the regulation of drug metabolism.

In addition, genes regulated by CBAS3 refer to genes that affect drug metabolism by regulating the expression level of CBAS3. These genes include transcription factors, RNA-binding proteins, etc. Studies have shown that the regulation of these genes is an important part of the regulation of drug metabolism.

In addition to being a drug target, CBAS3 also has other biological functions. For example, CBAS3 can regulate the cell cycle, affecting cell proliferation and apoptosis. In addition, CBAS3 can also regulate cell signaling and participate in cell death processes such as apoptosis and necrosis.

In recent years, with the development of high-throughput sequencing technology, researchers have conducted in-depth studies on the biological functions of CBAS3. These research results provide an important theoretical basis for the study of CBAS3 as a drug target.

Overall, CBAS3 is a very important drug target and is of great significance in the regulation of drug metabolism. With the deepening of research, CBAS3 is expected to become an important drug for the treatment of drug resistance and abnormal drug metabolism.

Protein Name: Cytochrome P450 Family 7 Subfamily B Member 1

Functions: A cytochrome P450 monooxygenase involved in the metabolism of endogenous oxysterols and steroid hormones, including neurosteroids (PubMed:10588945, PubMed:24491228). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:10588945, PubMed:24491228). Catalyzes the hydroxylation of carbon hydrogen bonds of steroids with a preference for 7-alpha position (PubMed:10588945, PubMed:24491228). Usually metabolizes steroids carrying a hydroxy group at position 3, functioning as a 3-hydroxy steroid 7-alpha hydroxylase (PubMed:24491228). Hydroxylates oxysterols, including 25-hydroxycholesterol and (25R)-cholest-5-ene-3beta,26-diol toward 7-alpha hydroxy derivatives, which may be transported to the liver and converted to bile acids (PubMed:9802883, PubMed:10588945). Via its product 7-alpha,25-dihydroxycholesterol, a ligand for the chemotactic G protein-coupled receptor GPR183/EBI2, regulates B cell migration in germinal centers of lymphoid organs, thus guiding efficient maturation of plasma B cells and overall antigen-specific humoral immune response (By similarity). 7-alpha hydroxylates neurosteroids, including 3beta-hydroxyandrost-5-en-17-one (dehydroepiandrosterone) and pregnenolone, both involved in hippocampus-associated memory and learning (PubMed:24491228). Metabolizes androstanoids toward 6- or 7-alpha hydroxy derivatives (PubMed:24491228)

The "CYP7B1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CYP7B1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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