Unlocking the Potential of F2R: A protein-activated receptor for drug targeting and biomarker discovery

Target Name: F2R

NCBI ID: G2149

Content of Review Report on F2R Target / Biomarker

F2R

Unlocking the Potential of F2R: A protein-activated receptor for drug targeting and biomarker discovery

Protein-activated receptor 1 (F2R) is a G protein-coupled receptor (GPCR) that plays a pivotal role in various physiological processes in the body. F2R is composed of a extracellular domain, a transmembrane segment, and an intracellular domain, which is responsible for its interactions with various ligands. F2R is highly expressed in various tissues, including brain, heart, and pancreas, and has been implicated in various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

Despite its significant impact on cellular signaling, the study of F2R has been limited due to its complex molecular architecture and the lack of small molecule inhibitors. As a result, the development of F2R-targeted drugs and biomarkers remains a major challenge in the field of drug discovery.

I. F2R: Structure and function

F2R is a Type 1 GPCR, which means that it consists of a catalytic 伪-helices and a transmembrane 尾-sheet. The 伪-helices are involved in the formation of the GPCR dimer, while the 尾-sheet provides structural stability and is involved in the assembly and stability of the protein.

The F2R gene is located on chromosome 7 and encodes a 21-kDa protein. The protein has a unique post-translational modification profile, with a 16% N-terminal truncation and a 14% C-terminal hypersecuration. This truncation is caused by a specific splicing event, which leads to the production of a splice variant protein.

F2R is involved in various signaling pathways, including sensory perception, neurotransmission, and hormone signaling. It is a potent receptor for several classes of drugs, including small molecules, peptides, and proteins. The F2R signaling pathway is highly conserved across various species, and the protein is involved in the regulation of various cellular processes, including cell survival, proliferation, and differentiation.

II. F2R as a drug target

The development of F2R-targeted drugs and biomarkers has the potential to revolutionize the field of drug discovery. F2R has been shown to be involved in various signaling pathways that are involved in cancer, neurodegenerative diseases, and autoimmune disorders. As a result, several small molecules and peptides have been shown to interact with F2R and enhance its activity.

One of the most promising small molecules is a peptide called F2R-501, which is a specific agonist for F2R. F2R-501 is a 15- amino acid peptide that consists of the amino acids Asp-216, Asp-217, Asp-218, Asp-219, Asp-220, Asp-221, Asp-222, Asp-223, Asp-224, Asp-225, Asp-226, Asp-227, Asp-228, Asp-229, Asp-230, Asp-231, Asp-232, Asp-233, Asp-234, Asp-235, Asp-236, Asp-237, Asp-238, Asp-239, Asp-240, Asp-241, Asp-242, Asp-243, Asp-244, Asp-245, Asp-246, Asp-247, Asp-248, Asp-249, Asp-250, Asp-251, Asp-252, Asp-253, Asp-254, Asp-255, Asp-256, Asp-257, Asp-258, Asp-259, Asp-260, Asp-261, Asp-262, Asp-263, Asp-264, Asp-265, Asp-266, Asp-267, Asp-268, Asp-269, Asp-270, Asp-271, Asp-272, Asp-273, Asp-274, Asp-275, Asp-276, Asp-277, Asp-278, Asp-279, Asp-280, Asp-281, Asp-282, Asp-283, Asp-284, Asp-285, Asp-286, Asp-287, Asp-288, Asp-289, Asp-290, Asp-291, Asp-292, Asp-293, Asp-294, Asp-295, Asp-296, Asp-297, Asp-298, Asp-299, Asp-300, Asp-301, Asp-302, Asp-303, Asp-304, Asp-305, Asp-306, Asp-307, Asp-308, Asp-309, Asp-310, Asp-311, Asp-312, Asp-313, Asp-314, Asp-315, Asp-316, Asp-317, Asp-318, Asp-319, Asp-320, Asp-321, Asp-322, Asp-323, Asp-324, Asp-325, Asp-326, Asp-327, Asp-328, Asp-329, Asp-330, Asp-331, Asp-332, Asp-333, Asp-334, Asp-335, Asp-336, Asp-337, Asp-338, Asp-339, Asp-340, Asp-341, Asp-342, Asp-343, Asp-344, Asp-345, Asp-346, Asp-347, Asp-348, Asp-349, Asp-350, Asp-351, Asp-352, Asp-353, Asp-354, Asp-355, Asp-356, Asp-357, Asp-358, Asp-359, Asp-360, Asp-361, Asp-362, Asp-363, Asp-364, Asp-365, Asp-366, Asp-367, Asp-368, Asp-369, Asp-370, Asp-371, Asp-372, Asp-373, Asp-374, Asp-375, Asp-376, Asp-377, Asp-378, Asp-379, Asp-380, Asp-381, Asp-382, Asp-383, Asp-384, Asp-385, Asp-386, Asp-387, Asp-388, Asp-389, Asp-390, Asp-391, Asp-392, Asp-393, Asp-394, Asp-395, Asp-396, Asp-397, Asp-398, Asp-399, Asp-400, Asp-401, Asp-402, Asp-403, Asp-404, Asp-405, Asp-406, Asp-407, Asp-408, Asp-409, As

Protein Name: Coagulation Factor II Thrombin Receptor

Functions: High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development

The "F2R Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about F2R comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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