ACSL4: An Enzyme Involved in ATP Production and Cellular Processes

Target Name: ACSL4

NCBI ID: G2182

ACSL4

ACSL4: An Enzyme Involved in ATP Production and Cellular Processes

ACSL4 (Long-chain-fatty-acid--CoA ligase 4) is a protein that is expressed in various organisms, including bacteria, archaea, and eukaryotes. It is a member of the Co-enzyme A (CoA) ligase family 4, which is involved in the citric acid cycle (also known as the Krebs cycle or TCA cycle).

The citric acid cycle is a central metabolic pathway that is involved in the production of energy from food. It is a complex process that involves the breakdown of food into smaller molecules, such as glucose, and the production of ATP, which is the energy currency of the cell. The CoA ligase are enzymes that are involved in the citric acid cycle, and they play a crucial role in the production of ATP from the citric acid cycle.

ACSL4 is a member of the CoA ligase 4 family, which is characterized by the presence of a specific active site on the protein that is responsible for catalyzing the ligase reaction. This site is known as the active site, and it is the location where the protein binds to the CoA ligand and initiates the ligase reaction.

The active site of ACSL4 is unique in that it contains a specific type of ligand, known as the long-chain fatty acid (LCFA). LCFA is a type of ligand that is derived from fatty acids, and it is characterized by its ability to bind to the active site of a CoA ligase. ACSL4 is able to bind to LCFA with high affinity, which allows it to efficiently catalyze the ligase reaction.

The ability of ACSL4 to catalyze the ligase reaction is important for its role in the production of ATP from the citric acid cycle. The citric acid cycle is a critical pathway for the production of ATP, and it is involved in the majority of cellular metabolism. ACSL4 is involved in the production of ATP from the citric acid cycle by catalyzing the transfer of the CoA ligand from the substrate to the active site of the CoA ligase.

In addition to its role in the production of ATP, ACSL4 is also involved in the regulation of various cellular processes. For example, ACSL4 has been shown to play a role in the regulation of cell growth and differentiation. Additionally, ACSL4 has also been shown to be involved in the regulation of cellular metabolism, such as the production of cholesterol and the metabolism of fatty acids.

As a potential drug target, ACSL4 is an attractive target for researchers because of its involvement in the production of ATP from the citric acid cycle and its role in the regulation of various cellular processes. Additionally, because ACSL4 is a protein that is expressed in various organisms, it is potential to be used as a biomarker for a variety of diseases.

In conclusion, ACSL4 is a unique and important protein that is involved in the production of ATP from the citric acid cycle and the regulation of various cellular processes. As a potential drug target and biomarker, ACSL4 is a promising target for researchers to study and develop new treatments for a variety of diseases.

Protein Name: Acyl-CoA Synthetase Long Chain Family Member 4

Functions: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:24269233, PubMed:22633490, PubMed:21242590). Preferentially activates arachidonate and eicosapentaenoate as substrates (PubMed:21242590). Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion (PubMed:21242590)

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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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