SLC29A4: A Potential Drug Target and Research Tool (G222962)

Target Name: SLC29A4

NCBI ID: G222962

SLC29A4

SLC29A4: A Potential Drug Target and Research Tool

SLC29A4 (OTTHUMP00000200583) is a protein that is expressed in various tissues throughout the body. It is a member of the SLC family of transmembrane proteins, which are known for their ability to regulate the concentration of ions and solutes across the membrane. SLC29A4 is specifically known for its role in the regulation of sodium levels in the body.

SLC29A4 is a 29-kDa protein that is expressed in the brain, heart, liver, and kidneys. It is primarily localized to the outer membrane of the membrane, but it can also be found in the cytoplasm. SLC29A4 is a monomeric protein, which means that it is composed of a single polypeptide chain.

SLC29A4 is involved in the regulation of sodium levels in various tissues. It is a critical protein for the proper functioning of the nervous system, as it helps to maintain the resting membrane potential of the brain. SLC29A4 is also involved in the regulation of the levels of other ions, such as potassium and chloride ions, in the body.

SLC29A4 is a potential drug target for various diseases. Its role in the regulation of sodium levels makes it an attractive target for treatments that are aimed at restoring normal ion balance in the body. For example, SLC29A4 has been suggested as a potential therapeutic target for the treatment of hypertension, which is characterized by high blood pressure.

SLC29A4 may also be a biomarker for certain diseases. Its role in the regulation of sodium levels makes it an potential indicator of the presence of certain health conditions. For example, individuals with heart failure may have increased levels of SLC29A4 in their urine, which could be used as a diagnostic marker for this disease.

SLC29A4 is also a potential research tool for studying the underlying mechanisms of certain diseases. Its role in the regulation of sodium levels makes it an attractive target for study in a variety of organisms, including humans. For example, researchers may use SLC29A4 as a tool to study the effects of certain drugs on the regulation of sodium levels in the body.

In conclusion, SLC29A4 is a protein that is expressed in various tissues throughout the body. It is a member of the SLC family of transmembrane proteins and is involved in the regulation of sodium levels in the body. As a potential drug target and biomarker, SLC29A4 is a promising target for the treatment of various diseases. Further research is needed to fully understand its role in the regulation of ion balance in the body and its potential as a therapeutic or research tool.

Protein Name: Solute Carrier Family 29 Member 4

Functions: Electrogenic voltage-dependent transporter that mediates the transport of a variety of endogenous bioactive amines, cationic xenobiotics and drugs (PubMed:15448143, PubMed:16099839, PubMed:16873718, PubMed:17018840, PubMed:17121826, PubMed:20592246, PubMed:20858707, PubMed:22396231, PubMed:31537831). Utilizes the physiologic inside-negative membrane potential as a driving force to facilitate cellular uptake of organic cations (PubMed:15448143, PubMed:20592246, PubMed:22396231). Functions as a Na(+)- and Cl(-)-independent bidirectional transporter (PubMed:15448143, PubMed:16099839, PubMed:22396231, PubMed:31537831). Substrate transport is pH-dependent and enhanced under acidic condition, which is most likely the result of allosteric changes in the transporter structure (PubMed:16873718, PubMed:17018840, PubMed:20592246, PubMed:22396231, PubMed:31537831). Implicated in monoamine neurotransmitters uptake such as serotonin, dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, histamine and tyramine, thereby supporting a role in homeostatic regulation of aminergic neurotransmission in the central nervous system (PubMed:15448143, PubMed:16099839, PubMed:17018840, PubMed:17121826, PubMed:20858707, PubMed:22396231). Also responsible for the uptake of bioactive amines and drugs through the blood-cerebrospinal fluid (CSF) barrier, from the CSF into choroid plexus epithelial cells, thereby playing a significant role in the clearance of cationic neurotoxins, xenobiotics and metabolic waste in the brain (By similarity). Involved in bidirectional transport of the purine nucleoside adenosine and plays a role in the regulation of extracellular adenosine concentrations in cardiac tissues, in particular during ischemia (PubMed:16873718, PubMed:20592246, PubMed:31537831). May be involved in organic cation uptake from the tubular lumen into renal tubular cells, thereby contributing to organic cation reabsorption in the kidney (PubMed:17018840). Also transports guanidine (PubMed:16099839)

The "SLC29A4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SLC29A4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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