SLC37A3: A Key Protein in The Transport of Glycerol-3-Phosphate Across Cell Membranes

Target Name: SLC37A3

NCBI ID: G84255

SLC37A3

SLC37A3: A Key Protein in The Transport of Glycerol-3-Phosphate Across Cell Membranes

SLC37A3, a member of the SLC ( solute carrier family 37 ) family, is a protein that is expressed in various tissues and organs throughout the body. It is primarily known for its role in the transport of glycerol-3-phosphate (G3P) across cell membranes. G3P is a key intermediate step in the metabolism of triacylglycerols, which are a common type of lipid in the body. SLC37A3 has been shown to play a crucial role in the delivery of G3P from the cytosol to the endoplasmic reticulum, where it can be involved in various cellular processes such as signaling pathways and protein synthesis.

SLC37A3 is a transmembrane protein, which means that it spans the cell membrane and is involved in the regulation of the movement of molecules across the membrane. It has a unique structure that consists of a transmembrane region and an intracellular region. The transmembrane region is composed of four beta-helices, which are responsible for the protein's transmembrane movement. The intracellular region is a unique region that is involved in the regulation of SLC37A3's activity.

SLC37A3 is regulated by various factors, including pH, temperature, and substrate concentration. These factors can alter the structure and function of the protein, allowing it to interact with other cellular components and participate in different cellular processes. One of the most well-studied regulation of SLC37A3 is the interaction with the protein known as TrkB. TrkB is a G protein-coupled receptor that is involved in the regulation of intracellular signaling pathways. It has been shown that the interaction between SLC37A3 and TrkB plays a role in the regulation of SLC37A3's activity.

SLC37A3 has also been shown to interact with other proteins, including the protein known as TAP. TAP is a protein that is involved in the regulation of protein synthesis and it has been shown to interact with SLC37A3. The interaction between SLC37A3 and TAP has been shown to play a role in the regulation of SLC37A3's activity and in the regulation of cellular processes such as cell growth and differentiation.

SLC37A3 is also known as G3P transporter and it is a key protein in the transport of G3P across cell membranes. G3P is a key intermediate step in the metabolism of triacylglycerols, which are a common type of lipid in the body. SLC37A3 has been shown to play a crucial role in the delivery of G3P from the cytosol to the endoplasmic reticulum, where it can be involved in various cellular processes such as signaling pathways and protein synthesis.

SLC37A3 is a potential drug target and it has been shown to have a role in various diseases. For example, SLC37A3 has been shown to be involved in the regulation of insulin sensitivity and inflammation. Insulin sensitivity is a condition in which the body's cells become less responsive to insulin, making it difficult for the body to use insulin to lower blood sugar levels. SLC37A3 has been shown to play a role in the regulation of insulin sensitivity by promoting the delivery of GLUT4 to the endoplasmic reticulum, which is a protein that is involved in the regulation of insulin sensitivity.

In addition, SLC37A3 has also been shown to be involved in the regulation of inflammation. Inflammation is a natural response of the immune system to injury or infection, but chronic inflammation can contribute to a range of diseases, including heart disease and cancer. SLC37A3 has been shown to play a role in the regulation of inflammation by promoting the delivery of pro-inflammatory

Protein Name: Solute Carrier Family 37 Member 3

Functions: Unlike the other SLC37 members, lacks glucose-6-phosphate antiporter activity (PubMed:21949678). In osteoclasts, forms a transporter complex with ATRAID for nitrogen-containg-bisphophonates (N-BPs) required for releasing N-BP molecules that have trafficked to lysosomes through fluid-phase endocytosis into the cytosol (PubMed:29745899)

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