SLC35B3: A Potential Drug Target and Biomarker for Brain Function

Target Name: SLC35B3

NCBI ID: G51000

SLC35B3

SLC35B3: A Potential Drug Target and Biomarker for Brain Function

SLC35B3, a member of the SLC family, is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. Its primary function is to transport and regulate the transport of certain molecules, such as amino acids and nucleotides, across the blood-brain barrier.

SLC35B3 is a 35kDa protein that is composed of 128 amino acid residues. It has a calculated pI of approximately 9.0 and a predicted localization in the membrane of a ~100 nanometer. SLC35B3 is predominantly expressed in the brain, with a highest expression level in the prefrontal cortex.

SLC35B3 has been identified as a potential drug target due to its unique structure and its involvement in the regulation of essential brain functions. One of the key functions of SLC35B3 is its role in the regulation of neurotransmitter homeostasis, which is critical for the proper functioning of the brain.

SLC35B3 has been shown to play a role in the regulation of dopamine homeostasis, which is important for the function of the reward system, motivation, and movement. SLC35B3 has been shown to interact with dopamine receptors and to regulate the transport of dopamine across the blood-brain barrier.

In addition to its role in neurotransmitter homeostasis, SLC35B3 has also been shown to be involved in the regulation of ion homeostasis. SLC35B3 has been shown to play a role in the regulation of sodium and potassium ions, which are essential for the proper functioning of various cellular processes.

SLC35B3 has also been shown to have potential as a biomarker for various neurological and psychiatric disorders. For example, SLC35B3 has been shown to be decreased in individuals with Alzheimer's disease, a neurodegenerative disorder that is characterized by the progressive loss of brain cells.

In addition to its potential as a drug target and biomarker, SLC35B3 is also of interest due to its unique structure and its involvement in the regulation of essential brain functions. SLC35B3 is a small protein that is expressed in various tissues of the body, making it a potential target for small molecule inhibitors. Further research is needed to fully understand the role of SLC35B3 in the regulation of brain function and to explore its potential as a drug target and biomarker.

Protein Name: Solute Carrier Family 35 Member B3

Functions: Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Compensates for the insufficient expression of SLC35B2/PAPST1 during the synthesis of sulfated glycoconjugates in the colon

The "SLC35B3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SLC35B3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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