SLC39A14: A Promising Gene for Drug Targets and Biomarkers (G23516)

Target Name: SLC39A14

NCBI ID: G23516

SLC39A14

SLC39A14: A Promising Gene for Drug Targets and Biomarkers

SLC39A14 is a gene that encodes a protein known as solute carrier family 39 member 14. The protein is a member of the SLC39 family, which is a well-known family of transmembrane proteins that play a crucial role in the transport of various substances across cell membranes. SLC39A14 is unique because it is a variant of the SLC39A14 gene, which has been shown to be associated with a range of physiological processes in both humans and animals.

One of the most promising aspects of SLC39A14 is its potential as a drug target. The SLC39A14 protein has been shown to be involved in a variety of cellular processes, including cell signaling, neurotransmission, and sensory perception. Additionally, SLC39A14 has been shown to play a role in the development and progression of certain diseases, such as cancer and neurodegenerative disorders.

SLC39A14 is also a potential biomarker for a variety of diseases. For example, studies have shown that high levels of SLC39A14 protein are associated with increased risk of certain cancers, such as breast and ovarian cancer. Additionally, SLC39A14 has been shown to be involved in the development of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease.

Another promising aspect of SLC39A14 is its potential to serve as a therapeutic agent. Studies have shown that SLC39A14 can be used to treat a variety of conditions, including cancer, neurodegenerative disorders, and respiratory diseases. For example, researchers have shown that SLC39A14 can be SLC39A14-containing channels used to treat certain forms of cancer by inhibiting the activity of cancer cells. Additionally, SLC39A14 has been shown to be effective in treating certain respiratory diseases, such as chronic obstructive pulmonary disease (COPD).

SLC39A14 is also a potential candidate for targeting with small molecules. The protein is known to have a clear structure, which makes it possible to design and synthesize small molecules that interact with SLC39A14. Studies have shown that SLC39A14 can be effectively targeted with small molecules, and that these molecules can have a variety of different effects on the protein. For example, one small molecule has been shown to inhibit the activity of SLC39A14, while another small molecule has been shown to activate it.

In conclusion, SLC39A14 is a gene that encodes a protein with a variety of potential roles in cellular and biological processes. Its unique variant status and involvement in a range of diseases make it an attractive target for research and therapeutic development. Further studies are needed to fully understand the biology and potential of SLC39A14, and to determine its utility as a drug target and biomarker.

Protein Name: Solute Carrier Family 39 Member 14

Functions: Electroneutral transporter of the plasma membrane mediating the cellular uptake of the divalent metal cations zinc, manganese and iron that are important for tissue homeostasis, metabolism, development and immunity (PubMed:15642354, PubMed:27231142, PubMed:29621230). Functions as an energy-dependent symporter, transporting through the membranes an electroneutral complex composed of a divalent metal cation and two bicarbonate anions (By similarity). Beside these endogenous cellular substrates, can also import cadmium a non-essential metal which is cytotoxic and carcinogenic (By similarity). Controls the cellular uptake by the intestinal epithelium of systemic zinc, which is in turn required to maintain tight junctions and the intestinal permeability (By similarity). Modifies the activity of zinc-dependent phosphodiesterases, thereby indirectly regulating G protein-coupled receptor signaling pathways important for gluconeogenesis and chondrocyte differentiation (By similarity). Regulates insulin receptor signaling, glucose uptake, glycogen synthesis and gluconeogenesis in hepatocytes through the zinc-dependent intracellular catabolism of insulin (PubMed:27703010). Through zinc cellular uptake also plays a role in the adaptation of cells to endoplasmic reticulum stress (By similarity). Major manganese transporter of the basolateral membrane of intestinal epithelial cells, it plays a central role in manganese systemic homeostasis through intestinal manganese uptake (PubMed:31028174). Also involved in manganese extracellular uptake by cells of the blood-brain barrier (PubMed:31699897). May also play a role in manganese and zinc homeostasis participating in their elimination from the blood through the hepatobiliary excretion (By similarity). Also functions in the extracellular uptake of free iron. May also function intracellularly and mediate the transport from endosomes to cytosol of iron endocytosed by transferrin (PubMed:20682781). Plays a role in innate immunity by regulating the expression of cytokines by activated macrophages (PubMed:23052185)

The "SLC39A14 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SLC39A14 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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