MRPS36: A Drug Target for Cancer and Neurodegenerative Diseases
MRPS36: A Drug Target for Cancer and Neurodegenerative Diseases
Mitochondrial Ribosomal Protein S36 (MRPS36) is a protein that plays a crucial role in the function of the mitochondria, which are energy-producing structures found in the cells of the body. It is a key component of the mitochondrial ribosome, which is the machinery that creates the building blocks of proteins. Mutations in the MRPS36 gene have been linked to a variety of diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. As a result, MRPS36 has emerged as a promising drug target and biomarker for a variety of diseases.
The ribosome is the largest protein-producing machine in the cell, responsible for creating the majority of the proteins that are synthesized in the cell. It is made up of a protein called rRNA (ribonucleic acid), which is composed of a series of nuclei glycolic acids that are held together by a sugar bond. The rRNA molecule forms a highly specialized structure called a nucleotide chain, which is the basic unit of RNA. together by a hydrogen bond.
When a cell needs to synthesize a new protein, it begins to read the genetic code contained in its DNA. The RNA polymerase, which is a protein that comes from the cell's DNA, uses the information in the DNA to create a new RNA molecule . The new RNA molecule is then translated into a protein by the ribosome.
The ribosome is made up of a number of different subunits, which are responsible for different aspects of the translation process. One of the subunits is called S36, which is a protein that is composed of multiple domains. The S36 protein is involved in the assembly and function of the ribosome, and is a key component of the mitochondria.
Mutations in the MRPS36 gene have been linked to a variety of diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. For example, studies have shown that individuals with certain genetic mutations, such as those found in the BRCA gene, are at increased risk of developing breast cancer. In addition, research has suggested that MRPS36 mutations may be involved in the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.
In addition to its role in the ribosome, MRPS36 has also been shown to play a number of other roles in the cell. For example, it is involved in the regulation of mitochondrial dynamics, which is important for the proper functioning of the mitochondria. It is also involved in the transport of oxygen and electrons within the mitochondria, which is critical for the production of energy by the cell.
As a result of its involvement in so many important cellular processes, MRPS36 has generated a lot of interest in the potential use of drugs that target it. Studies have shown that inhibiting the activity of MRPS36 has the potential to be a useful treatment for a variety of diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases.
One of the challenges in studying MRPS36 is its location in the cell. The mitochondria are located inside the cells, and as a result, it is difficult to study them directly. However, research has shown that it is possible to study the effects of drugs on MRPS36 using a technique called biochemical assays. These assays involve the use of small molecules, such as drugs, to detect changes in the activity of MRPS36.
One of the most promising areas of research is the use of small molecules to inhibit the activity of MRPS36. Studies have shown that a variety of small molecules, including inhibitors of protein-protein interactions and inhibitors of the activity of the ribosome, have the potential to be effective in
Protein Name: Mitochondrial Ribosomal Protein S36
Functions: May be necessary to recruit DLD/E3 to the mitochondrial 2-oxoglutarate dehydrogenase complex (OGDC) core composed of OGDH/E1-DLST/E2, hence stabilizes the complex
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• general information;
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• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
MRPS36P4 | MRPS5 | MRPS6 | MRPS7 | MRPS9 | MRRF | MRS2 | MRS2P2 | MRTFA | MRTFB | MRTO4 | MS4A1 | MS4A10 | MS4A12 | MS4A13 | MS4A14 | MS4A15 | MS4A18 | MS4A2 | MS4A3 | MS4A4A | MS4A4E | MS4A5 | MS4A6A | MS4A6E | MS4A7 | MS4A8 | MSANTD1 | MSANTD2 | MSANTD3 | MSANTD4 | MSC | MSC-AS1 | MSGN1 | MSH2 | MSH3 | MSH4 | MSH5 | MSH5-SAPCD1 | MSH6 | MSI1 | MSI2 | MSL1 | MSL2 | MSL3 | MSL3P1 | MSLN | MSLNL | MSMB | MSMO1 | MSMP | MSN | MSNP1 | MSR1 | MSRA | MSRA-DT | MSRB1 | MSRB1P1 | MSRB2 | MSRB3 | MSRB3-AS1 | MSS51 | MST1 | MST1L | MST1P2 | MST1R | MSTN | MSTO1 | MSTO2P | MSX1 | MSX2 | MSX2P1 | MT1A | MT1B | MT1DP | MT1E | MT1F | MT1G | MT1H | MT1HL1 | MT1IP | MT1JP | MT1L | MT1M | MT1P1 | MT1P3 | MT1X | MT1XP1 | MT2A | MT3 | MT4 | MTA1 | MTA1-DT | MTA2 | MTA3 | MTAP | MTARC1 | MTARC2 | MTATP6P1 | MTATP8P1
