HIC2: A Non-Coding RNA Molecule with Multiple Functions (G23119)

Target Name: HIC2

NCBI ID: G23119

HIC2

HIC2: A Non-Coding RNA Molecule with Multiple Functions

HIC2, or HIC zbtb transcriptional repressor 2, is a non-coding RNA molecule that plays a critical role in cell biology. It is a key regulator of gene expression and has been implicated in a wide range of cellular processes, including cell proliferation, apoptosis , and inflammation. Despite its importance, HIC2 is not well understood, and there are limited research articles available on it. This lack of understanding may make it an attractive drug target or biomarker in the future.

HIC2 is a member of the HIC gene family, which includes several non-coding RNA molecules that play a role in the regulation of gene expression. These molecules are characterized by a conserved core domain and a unique five-carbon sugar terminus, which is composed of a uridine residue and a cytidine residue. HIC2 is unique in that it has a double-stranded structure, with a central regions that are composed of alternating periods of open and closed double-strands.

HIC2 is expressed in many different organisms, including mammals, birds, and fish. It is highly conserved across different species, with only minor differences in its sequence. HIC2 is primarily located in the nucleus of the cell, where it interacts with the nuclear matrix and other non-coding RNAs.

One of the most significant functions of HIC2 is its role as a regulator of gene expression. HIC2 has been shown to play a role in the regulation of cell adhesion, cell-cell signaling, and cell proliferation. For example, studies have shown that HIC2 can inhibit the activity of the transcription factor NF-E2, which is involved in cell adhesion and migration. Additionally, HIC2 has been shown to promote the activity of the transcription factor ASXL1, which is involved in cell proliferation and apoptosis.

Another function of HIC2 is its role in the regulation of DNA replication. HIC2 has been shown to play a role in the regulation of DNA replication by the enzyme DNRT1. This enzyme uses HIC2 as a template to generate a RNA molecule that can interact with the enzyme responsible for DNA replication, RNA polymerase II. This interaction between HIC2 and RNA polymerase II allows DNRT1 to accurately replicate the DNA template.

In addition to its roles in gene expression and DNA replication, HIC2 is also involved in the regulation of cell apoptosis. Studies have shown that HIC2 can induce cell apoptosis in response to various stimuli, including chemotherapy drugs and UV radiation. Additionally, HIC2 has been shown to play a role in the regulation of cell cycle progression, with studies showing that it can inhibit the activity of the enzyme cyclin D1.

Given its importance in these cellular processes, HIC2 is an attractive drug target or biomarker. Studies have shown that inhibiting the activity of HIC2 can lead to a variety of cellular effects, including the inhibition of cell growth, cell apoptosis, and DNA replication. Additionally , HIC2 has been shown to be involved in several diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

In conclusion, HIC2 is a non-coding RNA molecule that plays a critical role in the regulation of gene expression, cell adhesion, DNA replication, and cell apoptosis. Its unique structure and diverse functions make it an attractive drug target or biomarker for future research . Further studies are needed to fully understand the role of HIC2 in cellular processes and its potential as a drug.

Protein Name: HIC ZBTB Transcriptional Repressor 2

Functions: Transcriptional repressor

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