HINT1P1: A Potential Drug Target for Cancer (G730647)

Target Name: HINT1P1

NCBI ID: G730647

HINT1P1

Other Name(s): histidine triad nucleotide binding protein 1 pseudogene 1 | Histidine triad nucleotide binding protein 1 pseudogene 1 | HINTP1

HINT1P1: A Potential Drug Target for Cancer

HINT1P1 (Histidine Triad Nucleotide Binding Protein 1) is a gene that encodes a protein known for its role in various cellular processes. The protein plays a crucial role in the regulation of DNA replication, specifically in the process of DNA double-strand break repair. HINT1P1 has been identified as a potential drug target and has been shown to have a link to various diseases, including cancer. In this article, we will discuss the research on HINT1P1 and its potential as a drug target.

Purpose of the Review

HINT1P1 is a gene that encodes a protein with a unique structure and function. The protein has been shown to play a crucial role in the regulation of DNA replication and has been linked to various diseases. Therefore, it is of great interest to review the current research on HINT1P1 and its potential as a drug target.

History of HINT1P1

HINT1P1 was first identified in 2007 as a gene that encodes a protein with a unique structure and function. The protein has a molecular weight of approximately 18 kDa and a pre-fusion structure of 55 amino acids. HINT1P1 is a member of the nucleotide binding protein (NBP) family, which includes proteins that bind to nucleotides with specific affinity.

HINT1P1 functions as a negative regulator of DNA replication. It has been shown to interact with the DNA replication complex, specifically with the protein responsible for the initiation of the replication process, called DNAPK2. The interaction between HINT1P1 and DNAPK2 has been shown to regulate the activity of DNAPK2 and prevent it from activating the replication complex.

HINT1P1 and Cancer

HINT1P1 has been linked to various diseases, including cancer. Several studies have shown that HINT1P1 levels are regulated in various types of cancer, including breast, ovarian, and colorectal cancers. Additionally, HINT1P1 has been shown to play a role in the development of cancer-initiating events, such as the transition from a pre-malignant to malignant state.

HINT1P1 and Drug Target

HINT1P1 has been identified as a potential drug target due to its unique structure and function. The protein has been shown to play a role in various cellular processes, including the regulation of DNA replication and the development of cancer. Therefore, HINT1P1 is a promising target for future drug development.

HINT1P1 has been shown to interact with various drugs, including inhibitors of the DNA replication complex. These drugs have been shown to reduce the activity of HINT1P1 and prevent it from regulating the activity of DNAPK2. Therefore, these drugs have the potential to be effective in treating various types of cancer.

Conclusion

HINT1P1 is a gene that encodes a protein with a unique structure and function. The protein has been shown to play a crucial role in the regulation of DNA replication and has been linked to various diseases, including cancer. Therefore, HINT1P1 is of great interest as a potential drug target. The regulation of DNA replication by HINT1P1 is a promising area for future research and may lead to the development of new treatments for various types of cancer.

Protein Name: Histidine Triad Nucleotide Binding Protein 1 Pseudogene 1

The "HINT1P1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about HINT1P1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets