Target Name: FUT1
NCBI ID: G2523
Review Report on FUT1 Target / Biomarker Content of Review Report on FUT1 Target / Biomarker
FUT1
Other Name(s): GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1 | fucosyltransferase 1 (H blood group) | truncated FUT1 | truncated fucosyltransferase 1 | Galactoside alpha-(1,2)-fucosyltransferase 1 | HSC | galactoside 2-L-fucosyltransferase enzyme | 2-alpha-L-fucosyltransferase | FUT1_HUMAN | H | alpha(1,2)FT 1 | H glycosyltransferase | Alpha(1,2)FT 1 | alpha(1,2) fucosyltransferase 1 | type 1 galactoside alpha-(1,2)-fucosyltransferase FUT1 | H glycosytransferase | truncated alpha(1,2)fucosyltransferase | Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT1 | Fucosyltransferase 1 (H blood group), transcript variant 1 | Fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase) | nonfunctional fucosyltransferase 1 | FUT1 variant 1 | Blood group H alpha 2-fucosyltransferase | Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT1 | H antigen | Fucosyltransferase 1 | Alpha (1,2) fucosyltransferase | blood group H alpha 2-fucosyltransferase | HH | type 2 galactoside alpha-(1,2)-fucosyltransferase FUT1 | galactoside 2-alpha-L-fucosyltransferase

FUT1: Potential Drug Target and Biomarker for Various Diseases

FUT1 (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1) is a gene that encodes a protein involved in the metabolism of fucose, a type of sugar found in many fruits and vegetables. The protein produced by this gene has been shown to play a key role in the production of beta-D-galactoside 2-alpha-L-fucosyltransferase (beta-galactosyltransferase), a enzyme that is involved in the synthesis of beta-D-galactosylated proteins, which are a common type of sugar found in many foods, including fruits, vegetables, and dairy products.

FUT1 has been identified as a potential drug target and a biomarker for several diseases, including cancer, diabetes, and neurological disorders. Its role in the metabolism of fucose and the production of beta-galactosylated proteins has also led to its potential as a therapeutic agent for treating conditions that involve the manipulation of the gut microbiome, such as inflammatory bowel disease and obesity.

Studies have shown that alterations in the gut microbiome, often associated with lifestyle factors such as dietary changes and the use of antibiotics, can have a negative impact on the development and progression of several diseases, including cancer and neurological disorders. FUT1 has been shown to play a key role in the production of beta-galactosylated proteins, which are often found at higher levels in the gut microbiome than in the bloodstream. This suggests that alterations in the gut microbiome, which are often associated with lifestyle factors, may contribute to the development of diseases that involve the manipulation of the gut microbiome.

In addition to its potential as a drug target and biomarker, FUT1 has also been shown to be involved in several other biological processes that are relevant to human health. For example, the production of beta-galactosylated proteins has been shown to play a key role in the regulation of inflammation and immune responses. FUT1 has also been shown to be involved in the production of cellulose, a type of carbohydrate found in the cell walls of plants, which is thought to have a number of potential health benefits, including its potential as a source of energy and a source of fiber.

FUT1 has also been shown to be involved in the regulation of cellular processes that are relevant to the development and progression of many diseases, including cancer. For example, studies have shown that alterations in the levels of FUT1 in cancer cells can contribute to their increased sensitivity to chemotherapy and radiation therapy. In addition, the production of beta-galactosylated proteins has been shown to play a key role in the development of cancer, as has the regulation of cellular processes that are involved in cell division and apoptosis.

In conclusion, FUT1 (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1) is a gene that has been shown to play a key role in the production of beta-galactosylated proteins, which are often found at higher levels in the gut microbiome than in the bloodstream. The potential drug target and biomarker properties of FUT1 have led to its investigation as a potential therapeutic agent for a number of diseases, including cancer, diabetes, and neurological disorders. Further research is needed to fully understand the role of FUT1 in these and other biological processes, and to develop effective treatments for these and other diseases.

Protein Name: Fucosyltransferase 1 (H Blood Group)

Functions: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose residue of glycoconjugates through an alpha(1,2) linkage leading to H antigen synthesis that is an intermediate substrate in the synthesis of ABO blood group antigens (PubMed:2118655). H antigen is essential for maturation of the glomerular layer of the main olfactory bulb, in cell migration and early cell-cell contacts during tumor associated angiogenesis (PubMed:18205178). Preferentially fucosylates soluble lactose and to a lesser extent fucosylates glycolipids gangliosides GA1 and GM1a (By similarity)

The "FUT1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about FUT1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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