FURIN: A Potential Drug Target and Biomarker (G5045)
FURIN: A Potential Drug Target and Biomarker
FURIN, also known as paired basic amino acid cleaving enzyme, is a protein that is found in various organisms including bacteria, archaea, and eukaryotes. FURIN is a enzymes that possess a unique catalytic mechanism, where it cleaves specific pairs of amino acids as pairs, resulting in the formation of a new amino acid.
FURIN's unique mechanism of action has made it an attractive drug target and a potential biomarker for various diseases. The ability of FURIN to cleave specific pairs of amino acids as pairs makes it a potentially powerful tool for the development of new treatments for a variety of diseases.
One of the key advantages of FURIN as a drug target is its ability to interact with a wide range of small molecules, including drugs and other molecules that are found in the body. This makes it an attractive target for the development of both small molecule and protein-based therapeutics.
FURIN has also been shown to be involved in a number of important cellular processes, including the regulation of cell growth, differentiation, and inflammation. Its role in these processes makes it an attractive target for the development of new therapies for a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.
In addition to its potential as a drug target, FURIN is also a potential biomarker for a variety of diseases. Its ability to cleave specific pairs of amino acids as pairs makes it a unique tool for the detection and quantification of protein levels in the body. This makes it an attractive target for the development of diagnostic tools for a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.
FURIN has been shown to play a role in the regulation of a wide range of biological processes, including the regulation of cell growth, differentiation, and inflammation. Its role in these processes makes it an attractive target for the development of new therapies for a variety of diseases.
One of the key advantages of FURIN as a drug target is its ability to interact with a wide range of small molecules, including drugs and other molecules that are found in the body. This makes it an attractive target for the development of both small molecule and protein-based therapeutics.
FURIN has also been shown to be involved in a number of important cellular processes, including the regulation of cell growth, differentiation, and inflammation. Its role in these processes makes it an attractive target for the development of new therapies for a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.
In addition to its potential as a drug target and biomarker, FURIN is also an important player in the regulation of various cellular processes that are important for human health. For example, FURIN has been shown to play a role in the regulation of the immune system, which is important for protecting the body against the spread of infection and disease.
FURIN's unique mechanism of action and its role in important cellular processes make it an attractive target for the development of new therapies for a variety of diseases. As research continues to advance, the potential benefits of FURIN as a drug target and biomarker will continue to grow.
Protein Name: Furin, Paired Basic Amino Acid Cleaving Enzyme
Functions: Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif (PubMed:11799113, PubMed:1629222, PubMed:1713771, PubMed:2251280, PubMed:24666235, PubMed:25974265, PubMed:7592877, PubMed:7690548, PubMed:9130696). Mediates processing of TGFB1, an essential step in TGF-beta-1 activation (PubMed:7737999). Converts through proteolytic cleavage the non-functional Brain natriuretic factor prohormone into its active hormone BNP(1-32) (PubMed:20489134, PubMed:21763278). By mediating processing of accessory subunit ATP6AP1/Ac45 of the V-ATPase, regulates the acidification of dense-core secretory granules in islets of Langerhans cells (By similarity)
The "FURIN Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about FURIN comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
FUS | FUT1 | FUT10 | FUT11 | FUT2 | FUT3 | FUT4 | FUT5 | FUT6 | FUT7 | FUT8 | FUT8-AS1 | FUT9 | FUZ | FXN | FXR1 | FXR2 | FXYD1 | FXYD2 | FXYD3 | FXYD4 | FXYD5 | FXYD6 | FXYD6-FXYD2 | FXYD7 | FYB1 | FYB2 | FYCO1 | FYN | FYTTD1 | FZD1 | FZD10 | FZD10-AS1 | FZD2 | FZD3 | FZD4 | FZD4-DT | FZD5 | FZD6 | FZD7 | FZD8 | FZD9 | FZR1 | G protein-Coupled Inwardly-Rectifying Potassium Channel (GIRK) | G Protein-Coupled Receptor Kinases (GRKs) | G0S2 | G2E3 | G2E3-AS1 | G3BP1 | G3BP2 | G6PC1 | G6PC2 | G6PC3 | G6PD | GA-binding protein | GAA | GAB1 | GAB2 | GAB3 | GAB4 | GABA(A) receptor | GABARAP | GABARAPL1 | GABARAPL2 | GABARAPL3 | GABBR1 | GABBR2 | GABPA | GABPAP | GABPB1 | GABPB1-AS1 | GABPB1-IT1 | GABPB2 | GABRA1 | GABRA2 | GABRA3 | GABRA4 | GABRA5 | GABRA6 | GABRB1 | GABRB2 | GABRB3 | GABRD | GABRE | GABRG1 | GABRG2 | GABRG3 | GABRG3-AS1 | GABRP | GABRQ | GABRR1 | GABRR2 | GABRR3 | GACAT1 | GACAT2 | GACAT3 | GAD1 | GAD2 | GADD45A | GADD45B
