FUT5: A Key Enzyme in Cellular Metabolism and Disease (G2527)

Target Name: FUT5

NCBI ID: G2527

FUT5

FUT5: A Key Enzyme in Cellular Metabolism and Disease

FUT5, also known as Alpha (1,3) fucosyltransferase, is an enzyme that plays a crucial role in cellular metabolism. It is involved in the transfer of fucose units from the cell cytoplasm to the cell nucleus, where they are added to the nuclear chromatin. This process is essential for the development and maintenance of cellular organelles, including the mitochondria and endoplasmic reticulum.

FUT5 is a protein that consists of 219 amino acids and has a molecular weight of 23.9 kDa. It is a single-stranded alpha-helices protein with a distinct N-terminal and C-terminal region. The N-terminal region includes a putative N -endopeptide anchor that is involved in the interaction with other proteins. The C-terminal region includes a putative C-endopeptide anchor that is involved in the interaction with DNA.

FUT5 is expressed in most tissues and cells, including muscle, liver, and kidney. It is also highly expressed in the placenta, where it is responsible for the transfer of fucose units to the developing fetal cells.

FUT5 is a good candidate for a drug target because of its unique structure and its involvement in cellular metabolism. Many diseases are caused by the dysfunction of FUT5, including Down syndrome, where individuals have a defect in the transfer of fucose units to the cell nucleus.

In addition to its role in Down syndrome, FUT5 is also involved in the development and maintenance of many other cellular organelles, including the brain, heart, and lungs. It is a key enzyme in the production of the myelin sheath in the brain and in the production of the blood vessels in the heart.

FUT5 is also involved in the regulation of cellular processes that are important for human health, such as cell growth, apoptosis, and inflammation. It is a key regulator of the cell cycle and has been shown to play a role in the regulation of cell division and the treatment of cancer.

In addition to its role in cellular metabolism, FUT5 is also a good candidate for a drug target because of its unique structure and its involvement in the development and maintenance of cellular organelles. Many diseases are caused by the dysfunction of FUT5, including Down syndrome, and FUT5 has also been shown to play a key role in the regulation of cellular processes that are important for human health.

Protein Name: Fucosyltransferase 5

Functions: Catalyzes preferentially the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl-beta-D-glucosamine (GlcNAc) of an N-acetyllactosamine unit (type 2 chain) of an oligosaccharide, or a glycoprotein- and a glycolipid-linked N-acetyllactosamine unit via an alpha (1,3) linkage and participates in the surface expression of VIM-2, Lewis X/SSEA-1 and sialyl Lewis X antigens (PubMed:14718375, PubMed:1740457, PubMed:7721776, PubMed:9737988, PubMed:17604274, PubMed:9737989, PubMed:29593094). Preferentially transfers fucose to the GlcNAc of an internal N-acetyllactosamine unit of a poly-N-acetyllactosamine chain acceptor substrate (PubMed:7721776, PubMed:17604274). Also catalyzes to a lesser extend the transfer of L-fucose to the GlcNAc of a type 1 (beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl) or H-type 1 (alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-D-GlcNAc) chain oligosaccharide via an alpha (1,4) linkage (PubMed:14718375, PubMed:1740457, PubMed:7721776, PubMed:9737988, PubMed:17604274). Preferentially catalyzes sialylated type 2 oligosaccharide acceptors over neutral type 2 or H type 2 (alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-GlcNAc) oligosaccharide acceptors (PubMed:1740457, PubMed:9737989). Lactose-based structures are also acceptor substrates (PubMed:1740457, PubMed:7721776)

The "FUT5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about FUT5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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