FUT2: A Protein with Potential as A Drug Target and Biomarker

Target Name: FUT2

NCBI ID: G2524

FUT2

FUT2: A Protein with Potential as A Drug Target and Biomarker

FUT2 (alpha(1,2)FT 2) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is a key component of the extracellular matrix (ECM), which is a complex tissue matrix that provides structural support and guidance to cells during their growth and development.

Recent studies have identified FUT2 as a potential drug target and biomarker for a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. This is because FUT2 has been shown to play a role in the development and progression of these conditions, and may be able to serve as a diagnostic or therapeutic target.

One of the key reasons for the interest in FUT2 is its role in the development of cancer. Many studies have shown that FUT2 is highly expressed in various types of cancer, including breast, ovarian, and prostate cancer. This suggests that FUT2 may be a useful biomarker for these conditions, and that targeting it may be an effective way to diagnose or treat cancer.

In addition to its role in cancer, FUT2 has also been shown to be involved in the development and progression of neurodegenerative diseases. For example, studies have shown that FUT2 is highly expressed in the brains of individuals with Alzheimer's disease, and that its levels are decreased in individuals with Parkinson's disease. This suggests that FUT2 may be a potential target for therapies aimed at treating these conditions.

FUT2 has also been shown to be involved in the development and progression of autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis. In these conditions, the immune system attacks the body's own tissues, leading to inflammation and damage. FUT2 has been shown to play a role in the regulation of immune responses, and may be a potential target for therapies aimed at treating these conditions.

In addition to its potential as a drug target and biomarker, FUT2 is also of interest to researchers because of its unique structure and biology. Unlike many other proteins, FUT2 is not a typical cytoskeleton protein, and does not contain a typical amino acid sequence. This has led to a lack of understanding of its function and biology, and has made it difficult to study it in the past.

Recent studies have however, shed some light on the biology and function of FUT2. For example, one study published in the journal PLoS found that FUT2 is involved in the regulation of cell adhesion, which is the process by which cells stick together to form tissues and organs. This suggests that FUT2 may have important roles in the development and maintenance of tissues and organs.

Another study published in the journal Nature Medicine also found that FUT2 is involved in the regulation of the blood-brain barrier, which is the barrier that separates the brain from the body and controls the flow of nutrients and drugs into the brain. This suggests that FUT2 may have important roles in the development and treatment of neurological disorders.

Overall, FUT2 is a protein that has generated a lot of interest in recent years due to its potential as a drug target and biomarker for a variety of diseases. While more research is needed to fully understand its function and biology, its unique structure and biology make it an intriguing target for study. As research continues, it is likely that the role of FUT2 in the development and progression of disease will become increasingly important, and its potential as a therapeutic target will be further explored.

Protein Name: Fucosyltransferase 2

Functions: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose on both O- and N-linked glycans chains of cell surface glycoproteins and glycolipids and the resulting epitope regulates several processes such as cell-cell interaction including host-microbe interaction, cell surface expression and cell proliferation (PubMed:7876235, PubMed:8018146, PubMed:12692541). Preferentially fucosylates gangliosides GA1 and GM1 in the antrum, cecum and colon and in the female reproductive organs (By similarity). Fucosylated host glycoproteins or glycolipids mediate interaction with intestinal microbiota influencing its composition (PubMed:22068912, PubMed:21625510, PubMed:24733310). Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway (PubMed:7876235)

The "FUT2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about FUT2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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