PHLPP1: A Protein Involved in Intracellular Signaling, Inflammation and Cell Survival

Target Name: PHLPP1

NCBI ID: G23239

PHLPP1

PHLPP1: A Protein Involved in Intracellular Signaling, Inflammation and Cell Survival

PHLPP1 (hSOP) is a protein that is expressed in various tissues of the body, including the brain, heart, and lungs. It is a member of the SOP family of proteins, which are known for their role in intracellular signaling.

One of the key functions of PHLPP1 is its role in intracellular signaling. It is involved in the regulation of cell signaling pathways, including the regulation of cell adhesion, migration, and invasion. PHLPP1 has been shown to play a role in the regulation of brain development and function, and is thought to be involved in the development and progression of various neurological disorders.

Another function of PHLPP1 is its role in the regulation of inflammation. It has been shown to play a role in the regulation of immune cell function and the regulation of inflammation. PHLPP1 has been shown to be involved in the regulation of the immune response to infection, and is thought to play a role in the development of autoimmune diseases.

In addition to its role in intracellular signaling and inflammation, PHLPP1 is also involved in the regulation of cell survival. It has been shown to play a role in the regulation of cell survival and proliferation, and is thought to be involved in the development and progression of various diseases.

Given its involvement in a wide range of cellular processes, PHLPP1 is a promising drug target. Researchers have identified several potential drug candidates that are currently being developed as treatments for various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

One of the most promising drug candidates for PHLPP1 is a small molecule inhibitor of PHLPP1 that is currently being developed as a treatment for neurodegenerative diseases. This drug candidate has been shown to be effective in animal models of a variety of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

Another promising drug candidate for PHLPP1 is a monoclonal antibody (MAb) that is currently being developed as a treatment for cancer. This MAb has been shown to be effective in preclinical studies, and is being tested in clinical trials for the treatment of various types of cancer.

While there is currently no cure for many of the diseases that are associated with PHLPP1, researchers are hopeful that new treatments will be developed that can help to manage these conditions. By targeting PHLPP1 with drugs or other therapeutic approaches, researchers hope to be able to improve the quality of life for those patients.

Protein Name: PH Domain And Leucine Rich Repeat Protein Phosphatase 1

Functions: Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed:19079341). Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity)

The "PHLPP1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PHLPP1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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