GABRG2: A Potential Drug Target and Biomarker (G2566)

Target Name: GABRG2

NCBI ID: G2566

GABRG2

GABRG2: A Potential Drug Target and Biomarker

GABRG2 (Gamma-aminobutyric acid type A receptor subunit gamma2, transcript variant 2) is a non-c coding RNA (ncRNA) that has been shown to play a critical role in various physiological processes in the brain. Its primary function is to regulate the activity of the GABAergic neurotransmitter, GABA (Gamma-aminobutyric acid), which is known for its inhibitory effects on neural activity. GABRG2 is a GABAergic receptor that is expressed in many different tissues and cells throughout the body, including the brain.

Recent studies have identified GABRG2 as a potential drug target and biomarker for various neurological and psychiatric disorders. Its function in modulating GABA neurotransmission has been implicated in a wide range of neurotranscriptional processes, including the regulation of synaptic plasticity, neuronal excitability, and stress resilience. As such, GABRG2 has been identified as a promising target for the development of new therapeutic strategies for a variety of psychiatric and neurological conditions.

One of the key challenges in studying GABRG2 as a drug target is its complex and highly regulated gene expression. GABRG2 is a highly transcribed gene that is expressed in a variety of tissues and cells, including the brain. However, its expression levels can be highly regulated variable depending on the cell type and the environmental conditions. This makes it difficult to study the molecular mechanisms underlying its function as a drug target.

One way to study GABRG2 is through its expression levels. Researchers have used RNA sequencing (RNA-seq) to identify the differential expression of GABRG2 in various tissues and cells, including the brain. These studies have revealed that GABRG2 is highly expressed in the brain and that its expression levels can be modulated by a variety of factors, including drugs, knockdown, and RNA interference.

In addition to its expression, another way to study GABRG2 is through its function as a drug target. Researchers have used various techniques to determine the effects of drugs on GABRG2 expression and its function as a receptor. For example, they have used pharmacological agents to manipulate GABRG2 expression levels and have used optogenetic tools to study its function as an attractive drug target. These studies have shown that GABRG2 plays a crucial role in the modulation of neuronal activity and that its dysfunction is implicated in a wide range of neurological and psychiatric disorders.

GABRG2 has also been shown to be involved in the regulation of synaptic plasticity, which is the ability of the brain to change and adapt over time. Synaptic plasticity is a critical factor in the development and maintenance of neural circuits and is implicated in a wide range of cognitive functions. As such, GABRG2 has been shown to play a crucial role in the regulation of synaptic plasticity and its dysfunction has been implicated in a variety of cognitive impairments.

In addition to its role in synaptic plasticity, GABRG2 has also been shown to be involved in the regulation of neuronal excitability and stress resilience. Neuronal excitability is the ability of neurons to generate electrical impulses, which are essential for the function of the nervous system. Stress resilience is the ability of the brain to cope with and recover from the effects of stress, which is a critical factor in the regulation of mental health. GABRG2 has been shown to play a crucial role in both of these processes and its dysfunction has been implicated in a wide range of psychiatric and neurological disorders.

GABRG2 has also been shown to play a role in the regulation of inflammation and neurodegeneration. Inflammation is a critical factor in the development and progression of many diseases, including psychiatric and neurological disorders. Neurodegeneration is the progressive loss of neural cells and is a

Protein Name: Gamma-aminobutyric Acid Type A Receptor Subunit Gamma2

Functions: Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:2538761, PubMed:29950725). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:23909897, PubMed:25489750, PubMed:27864268). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity (PubMed:23909897, PubMed:25489750). The alpha2/beta2/gamma2 receptor exhibits synatogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity)

The "GABRG2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GABRG2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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