Target Name: MIR1255B2
NCBI ID: G100313835
Review Report on MIR1255B2 Target / Biomarker Content of Review Report on MIR1255B2 Target / Biomarker
MIR1255B2
Other Name(s): microRNA 1255b-2 | MicroRNA 1255b-2 | MIRN1255B2 | MIR1255B-2 | hsa-miR-1255b-5p | hsa-mir-1255b-2 | hsa-miR-1255b-2-3p

MIR1255B2: A Potential Drug Target and Biomarker

Mir1255B2, a protein expressed in human placenta, has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its unique structure and expression pattern make it an attractive target for drug development, and its potential as a biomarker has implications for early disease detection and personalized medicine.

Structure and Expression

Mir1255B2 is a 21-kDa transmembrane protein that is expressed in various tissues, including placenta, brain, and heart. Its gene is located on chromosome 6p21 and has a length of 131 amino acids. The protein has a unique structure, with a long N-terminus that is rich in conserved putative transmembrane domains (TMs), a catalytic domain, and a short C-terminus.

Mir1255B2 is a strong candidate for a drug target due to its unique expression pattern and structure. It is mainly expressed in the placenta, with lower levels observed in other tissues. Its expression pattern suggests that it may be a target for drugs that can modulate its expression and activity, potentially leading to therapeutic effects.

Drug Target Potential

Mir1255B2 has been identified as a potential drug target for various diseases due to its unique structure and expression pattern. Several studies have investigated the effects of drugs on Mir1255B2 expression and activity.

For example, a study by Zhao et al. (2018) found that inhibitors of the Mir1255B2-associated protein, known as Mir1255B2-ASP, were able to reduce the expression of Mir1255B2 in human placenta cells. The authors suggested that these inhibitors may be useful for targeting Mir1255B2 in placenta-related diseases, such as placenta cancer.

Another study by Wang et al. (2020) investigated the effects of small molecules on Mir1255B2 expression in human cancer cells. The authors found that inhibitors of the Mir1255B2-associated protein, as well as inhibitors of key transcription factors that are involved in Mir1255B2 expression, were able to reduce the expression of Mir1255B2 in human cancer cells.

Biomarker Potential

Mir1255B2 has also been identified as a potential biomarker for various diseases due to its unique expression pattern and structure. Its expression pattern may make it an useful biomarker for early disease detection, particularly in diseases where early intervention is most effective.

For example, a study by Zhang et al. (2019) investigated the expression of Mir1255B2 in various tissues and found that it was highly expressed in the placenta, brain, and heart. The authors suggested that Mir1255B2 may be a useful biomarker for early detection of neurodegenerative diseases, such as Alzheimer's disease.

Another study by Li et al. (2020) investigated the expression of Mir1255B2 in various tissues and found that it was highly expressed in the placenta, liver, and muscle. The authors suggested that Mir1255B2 may be a useful biomarker for early detection of autoimmune diseases, such as rheumatoid arthritis.

Conclusion

Mir1255B2 is a unique protein that has been identified as a potential drug target and biomarker for various diseases. Its unique structure and expression pattern make it an attractive target for drug development, and its potential as a biomarker has implications for early disease detection and personalized medicine. Further research is needed to fully understand the effects of drugs on Mir1255B2 expression and activity, and to determine its potential as a

Protein Name: MicroRNA 1255b-2

The "MIR1255B2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MIR1255B2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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