MIR135A1: A Potential Drug Target for Cancer (G406925)
MIR135A1: A Potential Drug Target for Cancer
MIR135A1 (MIRN135-1) is a non-coding RNA molecule that has been identified as a potential drug target or biomarker for various diseases, including cancer. MIR135A1 is a key regulator of the microRNA (miRNA) pathway, which plays a crucial role in post-transcriptional gene regulation. aberrant miRNA levels have been implicated in the development and progression of many diseases, including cancer. Therefore, targeting MIR135A1 with small molecules or other therapeutic agents may be a promising strategy for the development of new treatments for these diseases.
MIR135A1 is a highly conserved non-coding RNA molecule that is expressed in various tissues and organs, including brain, heart, and pancreas. It is composed of 19 amino acid residues and has a predicted molecular weight of 20 kDa. MIR135A1 is located in the first exon of the gene MIR135, which encodes a protein with Putative Transmembrane Potential (PTP) domains.
MIR135A1 is a critical regulator of the miRNA pathway. It is a negative regulator of the sestrin gene, which encodes a protein involved in the miRNA pathway. MIR135A1 interacts with sestrin and prevents it from binding to its target gene, thereby regulating the levels of sestrins in the cell.
MIR135A1 is also a negative regulator of the let-28 gene, which encodes a protein involved in the miRNA pathway. MIR135A1 interacts with let-28 and prevents it from binding to its target gene, thereby regulating the levels of let-28s in the cell.
MIR135A1 has been shown to play a role in various diseases, including cancer. For example, MIR135A1 has been shown to be downregulated in various types of cancer, including breast, ovarian, and colorectal cancers. Additionally, MIR135A1 has been shown to be involved in the regulation of cellular processes that are important for cancer progression, such as cell migration, invasion, and angiogenesis.
MIR135A1 may also be a potential biomarker for cancer. Its downregulation in cancer cells may provide a sensitive marker for the presence of cancer. Additionally, its upregulation in cancer cells may be a potential target for therapeutic intervention. For example, small molecules that can increase MIR135A1 levels or inhibit its negative regulation may be developed as potential therapeutic agents for cancer treatment.
In conclusion, MIR135A1 is a promising drug target or biomarker for various diseases, including cancer. Its role in the regulation of the miRNA pathway and its involvement in the development and progression of cancer make it an attractive target for small molecules or other therapeutic agents. Further research is needed to fully understand the mechanisms of MIR135A1 and its potential as a therapeutic agent.
Protein Name: MicroRNA 135a-1
The "MIR135A1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MIR135A1 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
MIR135A2 | MIR135B | MIR136 | MIR137 | MIR137HG | MIR138-1 | MIR138-2 | MIR139 | MIR140 | MIR141 | MIR142 | MIR143 | MIR144 | MIR145 | MIR1468 | MIR1469 | MIR146A | MIR146B | MIR1470 | MIR1471 | MIR147A | MIR147B | MIR148A | MIR148B | MIR149 | MIR150 | MIR151A | MIR151B | MIR152 | MIR153-1 | MIR153-2 | MIR1537 | MIR1538 | MIR1539 | MIR154 | MIR155 | MIR155HG | MIR1587 | MIR15A | MIR15B | MIR16-1 | MIR16-2 | MIR17 | MIR17HG | MIR181A1 | MIR181A1HG | MIR181A2 | MIR181A2HG | MIR181B1 | MIR181B2 | MIR181C | MIR181D | MIR182 | MIR1825 | MIR1827 | MIR183 | MIR184 | MIR185 | MIR186 | MIR187 | MIR188 | MIR18A | MIR18B | MIR1908 | MIR1909 | MIR190A | MIR190B | MIR191 | MIR1910 | MIR1911 | MIR1912 | MIR1913 | MIR1914 | MIR1915 | MIR1915HG | MIR192 | MIR193A | MIR193B | MIR193BHG | MIR194-1 | MIR194-2 | MIR194-2HG | MIR195 | MIR196A1 | MIR196A2 | MIR196B | MIR197 | MIR1972-1 | MIR1972-2 | MIR1973 | MIR1976 | MIR198 | MIR199A1 | MIR199A2 | MIR199B | MIR19A | MIR19B1 | MIR19B2 | MIR200A | MIR200B
