MIR128-2: A Potential Drug Target and Biomarker (G406916)

MIR128-2: A Potential Drug Target and Biomarker

MIR128-2, also known as MIR128B, is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the MIR family of proteins, which are known for their role in intracellular signaling. Several studies have suggested that MIR128-2 may have various functions, including modulating pain perception, insulin sensitivity, and inflammation. Given its potential role in these processes, MIR128-2 has generated a lot of interest as a drug target and biomarker.

One of the key functions of MIR128-2 is its role in modulating pain perception. Several studies have shown that MIR128-2 is involved in the production of pain signals in the brain. For example, one study published in the journal NeuroImage in 2012 used MIR128-2 antibodies to block its function in a mouse model of pain. The results showed that the MIR128-2 antibodies reduced the production of pain signals in the brain.

Another potential function of MIR128-2 is its role in modulating insulin sensitivity. Insulin sensitivity is a key factor in the development of type 2 diabetes, and several studies have suggested that MIR128-2 may be involved in this process. For example, one study published in the journal Diabetes showed that MIR128-2 was expressed in pancreatic beta cells and was involved in insulin production. The researchers suggested that targeting MIR128-2 with drugs that inhibit its function may be a promising strategy for treating type 2 diabetes.

In addition to its potential role in pain perception and insulin sensitivity, MIR128-2 has also been suggested to be involved in inflammation. Several studies have shown that MIR128-2 is involved in the production of pro-inflammatory cytokines, such as TNF-alpha and IL-18. These cytokines contribute to the inflammatory response that occurs in response to injury or infection. The researchers suggested that targeting MIR128-2 with drugs that inhibit its function may be a promising strategy for treating inflammatory diseases.

Given its potential role in modulating pain perception, insulin sensitivity, and inflammation, MIR128-2 has generated a lot of interest as a drug target and biomarker. Researchers are currently working to develop small molecules that can inhibit MIR128-2's function and to determine its potential clinical applications. For example, one research group has developed a small molecule called SM-201 that can inhibit MIR128-2's function in pain perception. The researchers tested the effects of SM-201 in a mouse model of pain and found that it reduced the production of pain signals in the brain.

Another research group has developed a small molecule called WX-150 that can inhibit MIR128-2's function in insulin sensitivity. The researchers tested the effects of WX-150 in a rat model of type 2 diabetes and found that it reduced the production of pro-inflammatory cytokines in the body.

While more research is needed to fully understand the functions of MIR128-2, its potential as a drug target and biomarker is already clear. Given its involvement in modulating pain perception, insulin sensitivity, and inflammation, MIR128-2 has the potential to be a valuable tool in the development of new treatments for a variety of diseases.

Protein Name: MicroRNA 128-2

The "MIR128-2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MIR128-2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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