Targeting S100A14: Potential Strategies and Considerations (G57402)

Target Name: S100A14

NCBI ID: G57402

S100A14

Targeting S100A14: Potential Strategies and Considerations

S100A14 (BCMP84) is a protein that is expressed in various tissues of the body, including the brain, heart, and gastrointestinal tract. It is a member of the S100 family of proteins, which are known for their role in cell signaling and cytoskeletal organization . S100A14 has been shown to play a role in several physiological processes, including cell adhesion, migration, and invasion.

One of the unique features of S100A14 is its ability to interact with several different cell surface molecules. This protein has been shown to interact with a wide range of molecules, including cadherins, E-cadherins, N-cadherins, and integrins. These interactions allow S100A14 to participate in a variety of different processes in the cell, including cell adhesion, migration, and invasion.

S100A14 has also been shown to play a role in several diseases and conditions, including cancer, neurodegenerative diseases, and autoimmune disorders. For example, studies have shown that S100A14 is often overexpressed in various types of cancer, and that this overexpression is associated with poor prognosis. In addition, S100A14 has also been shown to be involved in several neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

Despite the potential clinical applications of S100A14 as a drug target, there are currently no known drugs that are specifically designed to target this protein. This is likely due to the fact that S100A14 is expressed in many different tissues of the body, and it is difficult to design a drug that can specifically target this protein in all of these tissues.

However, there are several potential strategies that could be used to target S100A14. For example, one approach could be to use small molecules or antibodies that specifically interact with S100A14 to block its function. This could be done by targeting specific residues on S100A14 that are involved in its function, such as the N-terminus or the A-helix.

Another approach could be to use drugs that specifically modulate the activity of S100A14. For example, drugs that inhibit the formation of S100A14-containing complexes with other cell surface molecules could potentially be used to reduce the activity of this protein. Similarly, drugs that enhance the formation of S100A14-containing complexes with other cell surface molecules could potentially be used to increase the activity of this protein.

In addition to these approaches, it is also important to consider the potential side effects of any drugs that are used to target S100A14. As with any drug, it is important to carefully consider the potential effects on other tissues and organs, as well as the potential for interactions with other medications.

Overall, S100A14 is a protein that has significant potential as a drug target. While there are currently no known drugs that are specifically designed to target this protein, there are several potential strategies that could be used to do so. Further research is needed to fully understand the role of S100A14 in biology and to develop effective treatments for diseases that are caused by its overexpression or dysfunction.

Protein Name: S100 Calcium Binding Protein A14

Functions: Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium

The "S100A14 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about S100A14 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets