S1PR4: GPCR Involved in Endothelial Differentiation and Other Processes

Target Name: S1PR4

NCBI ID: G8698

S1PR4

S1PR4: GPCR Involved in Endothelial Differentiation and Other Processes

S1PR4 (Endothelial differentiation G-protein coupled receptor 6) is a protein that is expressed in various tissues, including the brain, heart, and blood vessels. It is a member of the G-protein coupled receptor (GPCR) family, which is a large superfamily of transmembrane proteins that play a crucial role in cellular signaling. S1PR4 is known for its role in endothelial cell differentiation and has been shown to be involved in a variety of physiological processes, including blood vessel formation, angiogenesis, and inflammation.

S1PR4 is a GPCR that is characterized by its four transmembrane subunits, which are composed of an extracellular domain, a transmembrane segment, and an intracellular segment. The extracellular domain of S1PR4 consists of a N-terminal伪 helix and a C-terminal T-loop , which give the protein its characteristic X-shape. The transmembrane segment consists of a single transmembrane伪 helix and a single transmembrane尾 sheet, and the intracellular segment consists of a single intracellular伪 helix.

S1PR4 is involved in a variety of physiological processes that are important for maintaining tissue homeostasis and function. One of its main functions is to regulate the formation of blood vessels during embryonic development and postnatal development. During these processes, S1PR4 is involved in the regulation of cell proliferation, migration, and differentiation, as well as the regulation of cytoskeletal dynamics and cell-cell adhesion.

In addition to its role in blood vessel formation, S1PR4 is also involved in the regulation of inflammation and immune responses. It has been shown to be involved in the regulation of T cell development and activation, as well as the regulation of granulocyte function and differentiation.

S1PR4 is also a potential drug target and biomarker. Several studies have shown that inhibiting S1PR4 can have a variety of therapeutic effects, including the inhibition of cancer cell growth, the regulation of inflammation, and the regulation of blood vessel formation. In addition, S1PR4 has also been shown to be involved in a variety of diseases, including heart disease, neurodegenerative diseases, and autoimmune diseases.

Overall, S1PR4 is a GPCR that is involved in a variety of physiological processes and has been shown to be involved in a variety of diseases. Further research is needed to fully understand the role of S1PR4 in these processes and to develop effective therapies for the treatment of these diseases.

Protein Name: Sphingosine-1-phosphate Receptor 4

Functions: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes

The "S1PR4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about S1PR4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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