RXRA: A Nuclear Receptor Subfamily 2 Group B Member 1 (G6256)

Target Name: RXRA

NCBI ID: G6256

RXRA

RXRA: A Nuclear Receptor Subfamily 2 Group B Member 1

The nuclear receptor subfamily 2 group B member 1 (RXRA) is a protein that plays a crucial role in cell signaling. It is a key transcription factor that regulates various cellular processes, including cell growth, differentiation, and survival. RXRA is a protein that is expressed in many different tissues and cells throughout the body, including the brain, heart, and gastrointestinal tract.

One of the key functions of RXRA is its role as a transcription factor. It is a transcription factor that binds to specific DNA sequences and helps to regulate the expression of genes. This is important because RXRA is involved in many different cellular processes, including cell growth, differentiation, and survival.

Another important function of RXRA is its role as a signaling molecule. It is involved in the regulation of various signaling pathways, including the TGF-β pathway and the Wnt pathway. These signaling pathways are important for cell growth, differentiation, and survival, and RXRA plays a key role in regulating them.

RXRA is also involved in the regulation of cellular processes that are important for the development and progression of various diseases, including cancer. It is a known risk factor for the development of certain types of cancer, and it is also involved in the regulation of the growth and progression of cancer cells.

Despite its importance, RXRA is not well understood. There are currently very few studies that have been conducted to investigate its role in cell signaling and its potential as a drug target. However, studies suggest that RXRA may be a promising drug target due to its involvement in various cellular processes that are important for the development and progression of various diseases.

In conclusion, RXRA is a protein that plays a crucial role in cell signaling and has been shown to be involved in the regulation of various cellular processes that are important for the development and progression of various diseases. Further research is needed to fully understand its role and its potential as a drug target.

Protein Name: Retinoid X Receptor Alpha

Functions: Receptor for retinoic acid that acts as a transcription factor (PubMed:11162439, PubMed:11915042). Forms homo- or heterodimers with retinoic acid receptors (RARs) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes (PubMed:10195690, PubMed:11162439, PubMed:11915042, PubMed:28167758, PubMed:17761950, PubMed:16107141, PubMed:18800767, PubMed:19167885). The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription (PubMed:10195690, PubMed:11162439, PubMed:11915042, PubMed:17761950, PubMed:28167758). The high affinity ligand for retinoid X receptors (RXRs) is 9-cis retinoic acid (PubMed:1310260). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (PubMed:20215566). On ligand binding, the corepressors dissociate from the receptors and coactivators are recruited leading to transcriptional activation (PubMed:20215566, PubMed:9267036). Serves as a common heterodimeric partner for a number of nuclear receptors, such as RARA, RARB and PPARA (PubMed:10195690, PubMed:11915042, PubMed:28167758, PubMed:29021580). The RXRA/RARB heterodimer can act as a transcriptional repressor or transcriptional activator, depending on the RARE DNA element context (PubMed:29021580). The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes (PubMed:10195690). Together with RARA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (PubMed:28167758). Acts as an enhancer of RARA binding to RARE DNA element (PubMed:28167758). May facilitate the nuclear import of heterodimerization partners such as VDR and NR4A1 (PubMed:12145331, PubMed:15509776). Promotes myelin debris phagocytosis and remyelination by macrophages (PubMed:26463675). Plays a role in the attenuation of the innate immune system in response to viral infections, possibly by negatively regulating the transcription of antiviral genes such as type I IFN genes (PubMed:25417649). Involved in the regulation of calcium signaling by repressing ITPR2 gene expression, thereby controlling cellular senescence (PubMed:30216632)

The "RXRA Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RXRA comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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