TAS2R31: A Potential Drug Target and Biomarker for Taste Receptors

Target Name: TAS2R31

NCBI ID: G259290

TAS2R31

TAS2R31: A Potential Drug Target and Biomarker for Taste Receptors

Introduction

Taste is an important sense in our body. There are taste buds on our mouth and tongue, which are responsible for sensing the taste and texture of food. TAS2R31 is a G protein-coupled receptor (GPCR), a member of the Taste receptor family, and is mainly expressed on the taste buds of the tongue. TAS2R31 plays an important role in taste perception and plays a key role in the perception of food taste and texture. However, the role of TAS2R31 in certain diseases, such as diabetes, obesity, and neurological diseases, has not yet been revealed. Therefore, TAS2R31 has become a research target of great concern. This article will introduce the structure, function, pharmacology and potential role of TAS2R31 in diseases.

Structure and function of TAS2R31

TAS2R31 is a GPCR that belongs to the Taste receptor family. GPCRs are composed of two main domains: the extracellular region and the intracellular region. The extracellular domain consists of an N-terminal 伪-helix, a central 尾-sheet, and a C-terminal domain. The intracellular domain consists of an 伪-helix, a 尾-sheet, and a 纬-chain. The 伪-helix of TAS2R31 consists of 50 amino acids, has a right-handed helical structure, and is highly conserved.

The main function of TAS2R31 is to sense the taste and texture of food. Chemicals in food, such as bitter, sweet and salty tastes, bind to ligands of TAS2R31 and trigger intracellular signaling pathways. These signaling pathways lead to the transmission of nerve impulses in the mouth and tongue, ultimately allowing us to perceive the taste and texture of food. Different isoforms of TAS2R31 play different roles in taste perception. For example, TAS2R31R1 is responsible for sensing sweet taste, TAS2R31R2 is responsible for sensing salty taste, and TAS2R31R3 is responsible for sensing bitter taste.

Pharmacological significance of TAS2R31

TAS2R31 has high prospects in the field of drug research and development. Currently, TAS2R31 has become the target of many drug studies, mainly focusing on the following aspects:

1. Anti-diabetic drugs: The role of TAS2R31 in the treatment of diabetes is unclear, but some studies have shown that activation of TAS2R31 can reduce blood sugar levels. Therefore, TAS2R31 may be a potential antidiabetic drug target.

2. Anti-obesity drugs: The role of TAS2R31 in obesity treatment has also attracted much attention. Studies have found that activation of TAS2R31 is related to the development and physiological processes of obesity. Therefore, TAS2R31 may be a potential anti-obesity drug target.

3. Nervous system diseases: The role of TAS2R31 in neurological diseases also deserves attention. The role of TAS2R31 in neural pain, neurodegenerative diseases, etc. has been confirmed. Therefore, TAS2R31 may be a potential drug target for neurological diseases.

Potential role of TAS2R31 in disease

The potential role of TAS2R31 in disease has been extensively studied. TAS2R31 is closely related to the onset and development of diseases such as diabetes, obesity, and neurological diseases.

1. Diabetes: Activation of TAS2R31 can reduce blood sugar levels, so TAS2R31 may be a potential anti-diabetic drug target.

2. Obesity: The role of TAS2R31 in obesity treatment has attracted much attention. Studies have found that activation of TAS2R31 is related to the development and physiological processes of obesity. Therefore, TAS2R31 may be a potential anti-obesity drug target.

3. Nervous system diseases: The role of TAS2R31 in neurological diseases also deserves attention. The role of TAS2R31 in neural pain, neurodegenerative diseases, etc. has been confirmed. Therefore, TAS2R31 may be a potential drug target for neurological diseases.

in conclusion

TAS2R31 is a GPCR that plays an important role in taste perception. TAS2R31 holds high promise in drug development, especially against diabetes, obesity, and neurological diseases

Protein Name: Taste 2 Receptor Member 31

Functions: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). Activated by the sulfonyl amide sweeteners saccharin and acesulfame K

The "TAS2R31 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TAS2R31 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets