GATA4: A Protein Playing A Crucial Role in Gene Regulation and DNA Binding

Target Name: GATA4

NCBI ID: G2626

GATA4

GATA4: A Protein Playing A Crucial Role in Gene Regulation and DNA Binding

GATA4, also known as GATA binding protein 4, is a protein that plays a crucial role in gene regulation and DNA binding. It is a member of the GATA family of proteins, which are known for their ability to recruit chromatin-remodeling complexes to specific genomic regions. GATA4 is a key regulator of gene expression in many organisms, including humans.

GATA4 is involved in the regulation of a wide range of cellular processes, including cell growth, apoptosis, and transcriptional regulation. It has been shown to play a role in the development and progression of many diseases, including cancer, neurodegenerative diseases, and developmental disorders.

Due to its involvement in so many cellular processes, GATA4 has become an attractive target for drug development. Researchers are actively searching for small molecules that can inhibit GATA4 activity and prevent its negative effects on cellular processes. These small molecules can then be used as potential drugs or biomarkers for a variety of diseases.

One of the challenges in studying GATA4 is its complex structure and the fact that it is expressed in a wide range of cell types. However, research into the biology of GATA4 has provided valuable insights into the mechanisms of its function and the potential targets for its inhibitors.

One of the key functions of GATA4 is its ability to recruit chromatin-remodeling complexes to specific genomic regions. These complexes, which include proteins such as HATs (hairless and timer-like proteins) and SWRMs (spiky-like RNA binding proteins), work together to physically alter the chromatin structure and accessibility.

GATA4 plays a critical role in the regulation of these complexes by its ability to interact with specific DNA-binding domains within these proteins. This interaction is driven by GATA4's N-terminal domain, which contains a conserved nucleotide-binding motif (NBM) that is known to interact with the DNA-binding domains of its partner proteins.

Several studies have shown that GATA4 interacts with a wide range of DNA-binding proteins, including HATs, SWRMs, and other transcription factors. These interactions are important for GATA4's ability to regulate gene expression and for its role in the regulation of cellular processes such as cell growth, apoptosis, and chromatin remodeling.

In addition to its role in the regulation of chromatin structure, GATA4 is also involved in the regulation of gene expression. It has been shown to play a critical role in the regulation of stem cell self-renewal and in the development of cancer. GATA4 has also been shown to play a role in the regulation of fetal development and in the aging process.

GATA4 has also been shown to play a role in the regulation of inflammation and immune response. It has been shown to be involved in the regulation of T cell development and in the regulation of immune cell function.

GATA4 is also involved in the regulation of protein degradation, which is important for maintaining the balance of intracellular proteins and for preventing the accumulation of misfolded proteins that can cause a variety of cellular problems.

GATA4 has been shown to play a role in the regulation of cell cycle progression and in the regulation of apoptosis. It has been shown to play a critical role in the regulation of G1 cell cycle progression and in the transition from G1 to G2 phase of the cell cycle. GATA4 has also been shown to play a role in the regulation of apoptosis, which is the process by which cells die and are removed from the body.

In addition to its role in the regulation of cellular processes, GATA4 has also been shown to play a role in the regulation of tissue repair and regeneration. It has been shown to play

Protein Name: GATA Binding Protein 4

Functions: Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development and function (PubMed:24000169, PubMed:27984724, PubMed:35182466). In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it down-regulates endocardial and endothelial gene expression (PubMed:27984724). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement (PubMed:20081228). Required during testicular development (PubMed:21220346). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, sphingosine-1-phosphate lyase (PubMed:15734735)

The "GATA4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GATA4 comprehensively, including but not limited to:
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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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