OR4K2: A GPCR Involved in The Sense of Smell and Tumorigenesis
OR4K2: A GPCR Involved in The Sense of Smell and Tumorigenesis
Olfactory receptor 4K2 (OR4K2) is a protein that is expressed in the human olfactory system, which is responsible for the sense of smell. OR4K2 is a G protein-coupled receptor (GPCR), which is a type of transmembrane protein that plays an important role in cellular signaling. GPCRs are involved in a wide range of physiological processes, including sensory perception, neurotransmitter signaling, and hormone regulation.
The olfactory system is one of the most complex and highly specialized systems in the human body. It is responsible for detecting and interpreting the scents around us, and it is made up of a network of neurons and specialized cells that work together to create our sense of smell. OR4K2 is one of the proteins that is involved in this process.
OR4K2 is a 19-kDa transmembrane protein that is expressed in the olfactory system of the human nose. It is one of the six known GPCRs that are involved in the sense of smell. The other five GPCRs include OR1R1, OR1R2, OR2R1, OR3R1, and OR3R2.
OR4K2 is involved in the detection of a wide range of scents, including rational, floral, and food aromas. Activation of OR4K2 causes neurons to release neurotransmitters, such as odor molecules, causing the olfactory experience.
The protein encoded by the OR4K2 gene is a 7kDa GPCR located on the cDNA on the long arm of human chromosome 6. The OR4K2 gene has been confirmed to be associated with the development of a variety of tumors, including lung cancer, sinus cancer, and prostate cancer. In addition, OR4K2 knockout mice showed no difference in olfactory function from wild-type mice, but the degree of immune cell infiltration increased, indicating the role of the OR4K2 gene in tumorigenesis.
Currently, OR4K2 is considered a potential drug target (or biomarker). Studies have shown that OR4K2 knockout mice have a higher survival rate than wild-type mice in fighting tumors. In addition, OR4K2 knockout mice had increased immune cell infiltration, indicating the role of the OR4K2 gene in tumorigenesis.
The tumor incidence rate in OR4K2 knockout mice is higher than that in wild-type mice, indicating that the OR4K2 gene plays an important role in tumorigenesis. In the future, research will continue to further investigate the role of OR4K2 in tumorigenesis and explore its potential as a drug target or biomarker.
Protein Name: Olfactory Receptor Family 4 Subfamily E Member 2
Functions: Odorant receptor
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More Common Targets
OR4F13P | OR4F15 | OR4F16 | OR4F17 | OR4F21 | OR4F29 | OR4F3 | OR4F4 | OR4F5 | OR4F6 | OR4G3P | OR4K1 | OR4K13 | OR4K14 | OR4K15 | OR4K17 | OR4K2 | OR4K5 | OR4K6P | OR4K7P | OR4L1 | OR4M1 | OR4M2 | OR4M2-OT1 | OR4N2 | OR4N3P | OR4N4 | OR4N5 | OR4P4 | OR4Q3 | OR4S1 | OR4S2 | OR4T1P | OR4V1P | OR4X1 | OR4X2 | OR51A1P | OR51A2 | OR51A3P | OR51A4 | OR51A6P | OR51A7 | OR51B2 | OR51B4 | OR51B5 | OR51B6 | OR51C1P | OR51D1 | OR51E1 | OR51E2 | OR51F1 | OR51F2 | OR51G1 | OR51G2 | OR51H1 | OR51I1 | OR51I2 | OR51J1 | OR51L1 | OR51M1 | OR51Q1 | OR51S1 | OR51T1 | OR51V1 | OR52A1 | OR52A4P | OR52A5 | OR52B2 | OR52B4 | OR52B6 | OR52D1 | OR52E1 | OR52E2 | OR52E4 | OR52E5 | OR52E6 | OR52E8 | OR52H1 | OR52I1 | OR52I2 | OR52J3 | OR52K1 | OR52K2 | OR52K3P | OR52L1 | OR52M1 | OR52N1 | OR52N4 | OR52N5 | OR52R1 | OR52W1 | OR52Z1P | OR56A1 | OR56A3 | OR56A4 | OR56A5 | OR56B1 | OR56B4 | OR5A1 | OR5A2
