CCDC88B: A Potential Drug Target and Biomarker (G283234)

Target Name: CCDC88B

NCBI ID: G283234

CCDC88B

CCDC88B: A Potential Drug Target and Biomarker

Introduction

CDC88B is a protein that is expressed in various tissues of the body, including the brain, spleen, and Peyer's patches of the small intestine. It is a member of the cryptodermal gene family 88 (CDC88) and is involved in the development and maintenance of the epithelial barrier. The epithelial barrier is a critical structure that separates various body systems and is responsible for maintaining the integrity of the body's internal environment. CCDC88B has been identified as a potential drug target and biomarker due to its unique structure and the involvement it plays in various physiological processes.

CDC88B's Structure and Functions

The structure of CCDC88B is unique, as it consists of a transmembrane domain and a cytoplasmic domain. The transmembrane domain is responsible for the protein's transmembrane properties, while the cytoplasmic domain is responsible for the protein's cytoplasmic localization. The unique structure of CCDC88B allows it to interact with various cell signaling pathways and to participate in the development and maintenance of the epithelial barrier.

CDC88B is involved in the development and maintenance of the epithelial barrier by regulating various cell signaling pathways. One of the key signaling pathways that is involved in the development of the epithelial barrier is the TGF-β signaling pathway. This pathway plays a crucial role in the development of the epithelial barrier by promoting the formation of tight junctions between epithelial cells. CCDC88B is known to interact with the TGF-β1 receptor, which is a key component of the TGF-β signaling pathway. This interaction between CCDC88B and the TGF- 尾1 receptor suggests that CCDC88B may be a potential drug target for the treatment of epithelial disorders.

CDC88B is also involved in the regulation of the Wnt signaling pathway, which is a critical signaling pathway that is involved in the development and maintenance of the epithelial barrier. The Wnt signaling pathway plays a crucial role in the formation of the epithelial barrier by promoting the formation of cadherins, which are important adhesion molecules that help to maintain the integrity of the epithelial barrier. CCDC88B is known to interact with the Wnt receptor, which is a key component of the Wnt signaling pathway. This interaction between CCDC88B and the Wnt receptor suggests that CCDC88B may be a potential biomarker for the diagnosis and treatment of epithelial disorders associated with the Wnt signaling pathway.

CDC88B's Role in Inflammation

Inflammation is a critical biological response that helps the body to defend itself against harmful substances that enter the body. However, chronic inflammation can lead to a host of diseases, including cancer. The role of CCDC88B in the regulation of inflammation is an area that requires further investigation.

CDC88B has been shown to play a role in the regulation of cytokine production, which is a critical step in the inflammatory response. CCDC88B is known to interact with the pro-inflammatory molecule, TNF-伪, which is involved in the regulation of cytokine production . This interaction between CCDC88B and TNF-伪 suggests that CCDC88B may be a potential biomarker for the diagnosis and treatment of inflammatory disorders.

Conclusion

In conclusion, CCDC88B is a unique protein that is involved in the development and maintenance of the epithelial barrier and in the regulation of various cell signaling pathways, including the TGF-β and Wnt signaling pathways. Its unique structure and functions make it a potential drug target and biomarker for the treatment of various diseases, including cancer and inflammatory disorders. Further investigation is needed to fully understand the role of CCDC88B in these biological processes and to develop effective treatments.

Protein Name: Coiled-coil Domain Containing 88B

Functions: Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4(+) and the CD8(+) compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation (By similarity). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC (PubMed:25762780). Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis (PubMed:21289099)

The "CCDC88B Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CCDC88B comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets