Target Name: CCL14
NCBI ID: G6358
Review Report on CCL14 Target / Biomarker Content of Review Report on CCL14 Target / Biomarker
CCL14
Other Name(s): chemokine (C-C motif) ligand 14 | chemokine CC-1/CC-3 | Chemokine CC-1/CC-3 | C-C motif chemokine 14 (isoform 2) | SY14 | SCYA14 | HCC-3 | HCC-1(4-74) | Small-inducible cytokine A14 | C-C motif chemokine ligand 14, transcript variant 2 | CCL14_HUMAN | HCC-1/HCC-3 | C-C motif chemokine 14 | MCIF | SCYL2 | Small inducible cytokine subfamily A (Cys-Cys), member 14 | Chemokine (C-C motif) ligand 14 | CCL14 variant 2 | new CC chemokine 2 | HCC-1(1-74) | CC-1 | HCC-1(9-74) | chemokine CC-3 | NCC2 | CKB1 | HCC-1(3-74) | small inducible cytokine subfamily A (Cys-Cys), member 14 | Chemokine CC-1 | NCC-2 | small-inducible cytokine A14 | hemofiltrate CC chemokine 1 | C-C motif chemokine ligand 14 | Chemokine CC-3 | CC-3 | HCC-1 | CKb1

CCL14: A Protein Involved in Cell Signaling and Cell Adhesion

CCL14, also known as chemokine ligand 14, is a protein that is expressed in various tissues throughout the body. It is a member of the chemokine family, which are a group of small signaling proteins that are involved in the regulation of cellular behavior. CCL14 is known for its unique structure, which consists of a long cytoplasmic tail that is composed of a series of basic amino acids.

The CCL14 protein is involved in a variety of cellular processes, including cell signaling, cell adhesion, and cell survival. It is a potent ligand for several different chemokines, which are proteins that are similar to CCL14. These chemokines include factors such as PDGF- beta, TGF-beta, and NF-kappa-B. CCL14 has been shown to interact with these molecules and to play a role in their signaling pathways.

CCL14 has also been shown to play a role in the regulation of cellular processes such as cell proliferation, differentiation, and apoptosis. It is a potent inhibitor of the protein kinase kinase (PKP) kinase, which is an enzyme that is involved in the regulation of cell growth and survival. CCL14 has also been shown to interact with the transcription factor p53, which is involved in the regulation of DNA damage repair and apoptosis.

CCL14 has also been shown to play a role in the regulation of cellular signaling pathways that are involved in cell adhesion, migration, and invasion. It is a potent attractor for cells that have lost contact with cadherins, which are a family of transmembrane proteins that are involved in cell-cell adhesion. CCL14 has also been shown to interact with the protein integrin (ASI), which is involved in the regulation of cell adhesion and migration.

In addition to its role in cellular signaling, CCL14 has also been shown to play a role in the regulation of cellular processes such as cell survival and differentiation. It is a potent inhibitor of the protein p53, which is involved in the regulation of DNA damage repair and apoptosis. CCL14 has also been shown to interact with the transcription factor p21, which is involved in the regulation of cell growth and apoptosis.

CCL14 has also been shown to play a role in the regulation of cellular signaling pathways that are involved in cell differentiation and plasticity. It is a potent attractor for cells that have been treated with the chemical P4, which is involved in the regulation of cell differentiation and plasticity. CCL14 has also been shown to interact with the protein slender, which is involved in the regulation of cell shape and movement.

In conclusion, CCL14 is a protein that is involved in a variety of cellular processes. It is a potent ligand for several different chemokines and has been shown to play a role in the regulation of cell signaling, adhesion, migration, and survival. CCL14 is also a potent inhibitor of the protein kinase kinase (PKP) and has been shown to interact with several transcription factors, including p53 and p21. Further research is needed to fully understand the role of CCL14 in cellular processes and its potential as a drug target or biomarker.

Protein Name: C-C Motif Chemokine Ligand 14

Functions: Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induces intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and is inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes, eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5

The "CCL14 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CCL14 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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