MIP-4: A Potential Drug Target Or Biomarker (G6362)
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MIP-4: A Potential Drug Target Or Biomarker
CCL18 (Macrophage inflammatory protein 4 (MIP-4)) is a protein that is expressed in the cytosol of macrophages, which are a type of white blood cell that play a crucial role in the immune system. MIP-4 is a 12-kDa protein that is involved in the recruitment and activation of macrophages, as well as the production of other pro-inflammatory cytokines.
Recent studies have suggested that MIP-4 may have potential as a drug target or biomarker for a variety of diseases, including cancer, inflammation, and autoimmune disorders. In this article, we will explore the biology and function of MIP-4, as well as its potential as a drug target or biomarker.
The biology and function of MIP-4
MIP-4 is a cytosolic protein that is expressed in the cytosol of macrophages. It is a 12-kDa protein that consists of two distinct regions: an N-terminal region that contains a unique N-terminal extension, and a C-terminal region that contains a series of conserved structural features.
The N-terminal region of MIP-4 contains a unique extension that is composed of a short amino acid sequence followed by a long non-coding region that contains a variety of putative cytoplasmic interactions. This region is thought to play a role in the recruitment of macrophages to the site of inflammation.
The C-terminal region of MIP-4 contains a series of conserved structural features that are involved in the regulation of inflammation. This region includes a region that is involved in the production of pro-inflammatory cytokines, as well as a region that is involved in the regulation of the expression of other genes involved in inflammation.
MIP-4 is involved in the recruitment and activation of macrophages
Macrophages are a type of white blood cell that play a crucial role in the immune system. They are able to phagocytose and destroy a wide variety of pathogens, including bacteria, viruses, and fungi. In order to recruit macrophages to the site of inflammation, MIP-4 is involved in the production of pro-inflammatory cytokines and the regulation of their interactions with macrophages.
Studies have shown that MIP-4 is involved in the recruitment of macrophages to the site of inflammation. For example, one study found that mice that were treated with the anti-inflammatory drug Ticagrelor showed increased numbers of macrophages in the site of inflammation compared to control mice. This increase in macrophages was associated with an increase in the levels of MIP-4 in the cytosol of the macrophages.
MIP-4 is also involved in the regulation of the activation and function of macrophages. For example, one study found that MIP-4 was involved in the regulation of the expression of genes involved in the production of pro-inflammatory cytokines, such as TNF-伪 and IL-12. This regulation of pro-inflammatory cytokine production was important for the activation and recruitment of macrophages to the site of inflammation.
MIP-4 may have potential as a drug target or biomarker
Recent studies have suggested that MIP-4 may have potential as a drug target or biomarker for a variety of diseases, including cancer, inflammation, and autoimmune disorders. MIP-4 has been shown to be involved in the regulation of inflammation, and may be a useful target for drugs that are designed to reduce inflammation. Additionally, MIP-4 has been shown to be involved in the regulation of pro-inflammatory cytokine production, and may be a useful target for drugs that are designed to inhibit pro-inflammatory cytokine production.
In conclusion, MIP-4 is a cytosolic protein that is expressed in the cytosol of
Protein Name: C-C Motif Chemokine Ligand 18
Functions: Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses
The "CCL18 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CCL18 comprehensively, including but not limited to:
• general information;
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• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
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• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
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