TSEN54: A Potential Drug Target and Biomarker for tRNA Splicing Enrichment

Target Name: TSEN54

NCBI ID: G283989

TSEN54

TSEN54: A Potential Drug Target and Biomarker for tRNA Splicing Enrichment

Transcriptional regulation is a complex process that involves various enzymes and factors, including RNA splicing. Splicing is the process by which non-coding regions of DNA are joined together to form functional RNA molecules. tRNA splicing is a critical post-transcriptional regulation that creates specific RNA species for protein synthesis. tRNA-splicing endonuclease subunit Sen54 is an enzyme involved in tRNA splicing and is essential for splicing efficiency. The Sen54 enzyme has been identified as a potential drug target and biomarker due to its unique function in cellular processes.

Understanding TSEN54

TSEN54 is an enzyme that belongs to the NHEJ class of proteins. This class of enzymes is known for their ability to generate short RNA snippets, known as exons, from long non-coding regions of DNA. TSEN54 is specific for tRNA splicing and is involved in the creation of exons that are added to the final RNA product.

TSEN54 functions by recognizing specific tRNA splicing sites in the 5' end of pre-mRNA and then exerts a cleavage step to remove the non-coding regions from the 3' end of the tRNA. This process creates a 21-base fragment that is added to the 3' end of the newly synthesized tRNA. The addition of these exons to the tRNA creates a more efficient RNA product that can be translated into protein.

TSEN54 has been shown to play a critical role in regulating gene expression and has been involved in various cellular processes, including cell growth, differentiation, and apoptosis. The enzyme has also been shown to be involved in the development and progression of various diseases, including cancer.

TSEN54 as a potential drug target

The identification of TSEN54 as a potential drug target is based on its unique function in generating specific RNA products from long non-coding regions of DNA. The ability of TSEN54 to create short RNA snippets from long non-coding regions makes it an attractive target for small molecules that can modulate the expression of specific genes.

TSEN54 has been shown to be involved in various cellular processes, including cell growth, differentiation, and apoptosis. Therefore, it is possible that TSEN54 may be a drug target that can be modulated with small molecules to induce cell proliferation, differentiate cells, or trigger apoptosis.

TSEN54 has also been shown to be involved in the development and progression of various diseases, including cancer. Therefore, it is possible that TSEN54 may be a drug target that can be used to treat cancer by modulating its expression.

The identification of TSEN54 as a potential drug target is an exciting area of research that has the potential to lead to the development of new treatments for a variety of diseases. Further studies are needed to understand the full function of TSEN54 and its potential as a drug target.

TSEN54 as a biomarker

The identification of TSEN54 as a potential drug target also implies that it may be a useful biomarker for certain diseases. The ability of TSEN54 to generate specific RNA products from long non-coding regions makes it an attractive target for small molecules that can modulate the expression of specific genes.

TSEN54 has been shown to play a critical role in regulating gene expression and has been involved in various cellular processes, including cell growth, differentiation, and apoptosis. Therefore, it is possible that TSEN54 may be a useful biomarker for the evaluation of certain diseases.

TS

Protein Name: TRNA Splicing Endonuclease Subunit 54

Functions: Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events

The "TSEN54 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TSEN54 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets