TRBV25-1: A Potential Drug Target and Biomarker for Heart Disease

Target Name: TRBV25-1

NCBI ID: G28562

TRBV25-1

Other Name(s): TRBV251 | TCRBV11S1A1T | T cell receptor beta variable 25-1 | TCRBV25S1

TRBV25-1: A Potential Drug Target and Biomarker for Heart Disease

Heart disease is a leading cause of death worldwide, accounting for approximately 17% of all deaths. It is a complex condition that can be caused by a variety of factors, including genetic, lifestyle, and environmental factors. While several medications have been developed to treat heart disease, there is still a high demand for more effective and personalized treatments.

One potential drug target for heart disease is TRBV25-1, a protein that is expressed in the hearts of many animals, including humans. TRBV25-1 has been shown to play a critical role in the development and progression of heart disease, and may be a valuable biomarker for heart disease.

The TRBV25-1 gene is located on chromosome 17q11.2 and encodes a protein that is expressed in the hearts of many animals, including humans. The protein has a molecular weight of approximately 41 kDa and is composed of 115 amino acid residues. TRBV25- 1 is localized to the endoplasmic reticulum and is predominantly expressed in the cardiac muscle.

Studies have shown that TRBV25-1 is involved in several important processes that are critical for heart development and function. One of the main functions of TRBV25-1 is to regulate the formation of new cardiac muscle cells, which is essential for the growth and development of the heart.

In addition, TRBV25-1 has been shown to play a role in the regulation of cardiac contractions. It has been shown to interact with several important cardiac proteins, including the protein calbindin, which is involved in the regulation of muscle contractions. This interaction between TRBV25-1 and calbindin suggests that TRBV25-1 may be involved in the regulation of cardiac contractions and in the development of heart disease.

Another function of TRBV25-1 is its role in the regulation of the heart's electrical activity. Studies have shown that TRBV25-1 is involved in the regulation of the heart's electrical activity, which is essential for the normal function of the heart.

In addition, TRBV25-1 has been shown to be involved in the regulation of inflammation in the heart. Studies have shown that TRBV25-1 is involved in the regulation of the immune response in the heart, which is important for the fight against infection and inflammation.

While more research is needed to fully understand the role of TRBV25-1 in heart disease, it is clear that TRBV25-1 is a promising drug target. Studies have shown that inhibiting TRBV25-1 activity may be an effective way to treat heart disease. Additionally, TRBV25-1 has been shown to be a valuable biomarker for heart disease, and may be used as a diagnostic tool in the future.

In conclusion, TRBV25-1 is a protein that is expressed in the hearts of many animals, including humans. It has been shown to play a critical role in the development and progression of heart disease and may be a valuable drug target or biomarker for heart disease. Further research is needed to fully understand the role of TRBV25-1 in heart disease, including its potential as a drug target and biomarker.

Protein Name: T Cell Receptor Beta Variable 25-1

Functions: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)

The "TRBV25-1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TRBV25-1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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