ZNF454: A Promising Drug Target for Liver Disease (G285676)
ZNF454: A Promising Drug Target for Liver Disease
ZNF454, also known as Zinc finger protein 454 (isoform 1), is a protein that is expressed in a wide range of tissues and cells in the human body. It is a member of the ZNF gene family, which is known for the involvement of Zinc finger transcription factor in the regulation of gene expression. ZNF454 is a 21-kDa protein that consists of 210 amino acid residues.
The ZNF gene family is a subset of the ZNF- transforminger gene family, which is characterized by the presence of a zinc finger gene element in the promoter region of the gene. ZNF454 is a single copy gene whose coding region includes a zinc finger Transcription factor binding site, a DNA binding site, an RNA binding site and a protein binding site. Zinc finger transcription factor is a transcription factor that can bind to the promoter region of genes to promote gene transcription.
ZNF454 is expressed in a variety of tissues and organs, including neurons, liver cells, and kidney cells. In the liver, the expression level of ZNF454 is higher, probably because the liver is one of the most metabolically active organs in the body, so more ZNF454 is needed to maintain the normal function of liver cells.
Research shows that ZNF454 plays an important role in liver disease. For example, the expression level of ZNF454 can be used to predict the severity of cirrhosis and can also serve as a biomarker of liver cell damage. In addition, ZNF454 can also serve as a potential drug target because many drugs interfere with the function of ZNF454.
The molecular structure of ZNF454 also suggests that it has potential drug target properties. The C-terminus of ZNF454 contains a benzimidazole ring structure, which is easily bound by drug molecules and interferes with the function of ZNF454. In addition, the D-terminus of ZNF454 contains an acidic amino acid residue, which is also easily bound by drug molecules, thereby affecting the activity of ZNF454.
Therefore, ZNF454 is a very promising drug target. Future research could focus on developing drugs based on ZNF454, as well as studying the role of ZNF454 in liver disease. In addition, the relationship between the structure and function of ZNF454 and its mechanism of action in organisms can also be studied.
Protein Name: Zinc Finger Protein 454
Functions: May be involved in transcriptional regulation
The "ZNF454 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZNF454 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
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