HCST: A Protein with Broad Implications for Disease Treatment

Target Name: HCST

NCBI ID: G10870

HCST

HCST: A Protein with Broad Implications for Disease Treatment

HCST (KAP10) is a protein that is expressed in various tissues of the body, including the brain, heart, and lungs. It is a key regulator of cell proliferation and has been implicated in a number of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the key functions of HCST is its role in cell signaling. It is a transcription factor that regulates the expression of genes in response to various signaling cues, including cytokines and growth factors. This regulation is essential for the growth, development, and survival of cells, and is closely tied to the development and progression of many diseases.

HCST has also been shown to play a key role in the regulation of cellular processes that are critical for normal development and function. For example, studies have shown that HCST is involved in the regulation of cell division and that it plays a role in the development of cancer. Additionally, HCST has been shown to be involved in the regulation of cell migration and that it plays a role in the development of neurodegenerative diseases.

In addition to its role in cell signaling, HCST has also been shown to play a key role in the regulation of cellular processes that are critical for normal function. For example, studies have shown that HCST is involved in the regulation of cell death, that it plays a role in the regulation of inflammation, and that it is involved in the regulation of the immune response.

Given the numerous roles that HCST has been shown to play in cellular processes, it is likely that it will be an attractive drug target for researchers. Studies have shown that HCST is involved in the development and progression of many diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Additionally, given its role in cell signaling, it is likely that HCST will be involved in the regulation of a wide range of cellular processes that are critical for normal function.

In conclusion, HCST is a protein that has been shown to play a key role in a wide range of cellular processes that are critical for normal function. As such, it is likely to be an attractive drug target for researchers and could potentially be used to treat a wide range of diseases. Further research is needed to fully understand the role of HCST in cellular processes and to determine its potential as a drug target.

Protein Name: Hematopoietic Cell Signal Transducer

Functions: Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways. Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells. In NK cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors. In T-cells, it provides primarily costimulation for TCR-induced signals. KLRK1-HCST receptor plays a role in immune surveillance against tumors and is required for cytolysis of tumors cells; indeed, melanoma cells that do not express KLRK1 ligands escape from immune surveillance mediated by NK cells

The "HCST Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about HCST comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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