HDAC4-AS1: A Potential Drug Target and Biomarker (G101928111)

Target Name: HDAC4-AS1

NCBI ID: G101928111

HDAC4-AS1

Other Name(s): HDAC4 antisense RNA 1, transcript variant 1 | HDAC4 antisense RNA 1

HDAC4-AS1: A Potential Drug Target and Biomarker

Human DNA double-strand break repair (DCR) is a crucial process that enables the stability and integrity of genetic information. DNA damage can occur due to various factors, such as mutations, errors, or aging. HDAC4-AS1, an antisense RNA 1 transcript variant of the HDAC4 gene, has been identified as a potential drug target and biomarker for various diseases.

The HDAC4 gene is a non-coding RNA molecule that plays a critical role in the repair of DNA double-strand breaks. The HDAC4 protein, a 24-kDa protein, is involved in the removal of homologous ends from double-strand breaks. It functions as an essential component of the DNA repair machinery, which is responsible for maintaining the integrity of genetic information.

HDAC4-AS1 is a unique transcript variant of the HDAC4 gene that has been identified by bioinformatics analysis. It is a 21-nt RNA molecule that is predominantly expressed in the brain and nervous system. HDAC4-AS1 has been shown to have unique functions in various cellular processes, including cell survival, cell proliferation, and neurotrophic signaling.

One of the most significant functions of HDAC4-AS1 is its role in neurotrophic signaling. Neurotrophic factors are essential for the survival and growth of neurons, and they play a crucial role in the development and maintenance of neural circuits. HDAC4-AS1 has been shown to regulate the activity of neurotrophic factors, such as brain-derived neurotrophic factor (BDNF) and TrkA, which are crucial for the survival and growth of neurons.

In addition to its role in neurotrophic signaling, HDAC4-AS1 has also been shown to be involved in cell survival and cell proliferation. It has been shown to play a role in the regulation of cell cycle progression, apoptosis, and cell survival. HDAC4-AS1 has been shown to interact with various cellular signaling pathways, including the PI3K/Akt signaling pathway, which is involved in the regulation of cell survival and proliferation.

The potential drug target for HDAC4-AS1 is its role in the regulation of neurotrophic signaling, cell survival, and cell proliferation. Drugs that can modulate these processes may have therapeutic benefits for various neurological and psychiatric diseases, such as Alzheimer's disease, Parkinson's disease, and neurodegenerative diseases.

In conclusion, HDAC4-AS1 is a unique transcript variant of the HDAC4 gene that has been identified as a potential drug target and biomarker for various diseases. Its unique functions in neurotrophic signaling, cell survival, and cell proliferation make it an attractive target for therapeutic intervention. Further studies are needed to fully understand the role of HDAC4-AS1 in various diseases and to develop effective treatments.

Protein Name: HDAC4 Antisense RNA 1

The "HDAC4-AS1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about HDAC4-AS1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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