HCRTR1: A Drug Target / Disease Biomarker (G3061)

Target Name: HCRTR1

NCBI ID: G3061

HCRTR1

HCRTR1: A Drug Target / Disease Biomarker

HCRTR1 is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is a key regulator of the cell cycle, and is involved in the development and maintenance of normal cell structure and function.

Hcrtr1 has also been shown to play a role in a variety of diseases, including cancer, neurodegenerative diseases, and developmental disorders. It has been identified as a potential drug target, due to its involvement in these diseases and its ability to regulate cell cycle progression.

One of the key functions of Hcrtr1 is its role in regulating the cell cycle. The cell cycle is the process by which a cell grows, replicates its DNA, and divides. Hcrtr1 is involved in regulating the length of the cell cycle, as well as the number of cycles that occur in the cell.

This is important because an imbalance in the cell cycle can lead to the development of cancer. For example, if the cell cycle is stuck in a state of persistent G1 phase, the cell may undergo a rapid cycle and eventually divide, leading to the formation of a tumor.

Hcrtr1 helps to prevent this by regulating the length of the S-phase, which is the stage of the cell cycle where the DNA is replicated. By shortening the S-phase, Hcrtr1 ensures that the cell cycle is completed in a timely manner, and that the cell does not undergo an unnecessary division.

Another function of Hcrtr1 is its role in the regulation of cell adhesion. Adhesion is the process by which cells stick together to form tissues and organs. Hcrtr1 is involved in the formation of tight junctions, which are the weakest type of cell adhesion.

This is important because tight junctions help to maintain the integrity of tissues and organs, by preventing cells from coming into direct contact with each other. Hcrtr1 dysfunction has been implicated in a variety of neurodegenerative diseases, including Alzheimer's and Parkinson's disease.

In addition to its role in cell cycle and cell adhesion, Hcrtr1 is also involved in the regulation of stem cell proliferation. Stem cells are a type of cell that have the ability to develop into any type of cell in the body. Hcrtr1 is involved in regulating the number of stem cells that are produced, as well as their ability to differentiate into different cell types.

This is important because stem cells have the potential to be used to treat a variety of diseases, including cancer, neurodegenerative diseases, and developmental disorders. Hcrtr1 dysfunction has been implicated in the development of some of these diseases, and may therefore be a useful target for new treatments.

In conclusion, Hcrtr1 is a protein that is involved in a variety of processes throughout the body, including cell cycle, cell adhesion, and stem cell proliferation. Its regulation of the cell cycle is important for the development and maintenance of normal cell structure and function. In addition, Hcrtr1 is also involved in the regulation of stem cell proliferation and has been implicated in the development of a variety of diseases. As a result, Hcrtr1 is a promising target for new treatments.

Protein Name: Hypocretin Receptor 1

Functions: Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide (PubMed:9491897, PubMed:26950369). Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding (PubMed:9491897, PubMed:26950369)

The "HCRTR1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about HCRTR1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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