HDAC5: A Promising Drug Target and Biomarker for the Treatment of Human Diseases

Target Name: HDAC5

NCBI ID: G10014

HDAC5

HDAC5: A Promising Drug Target and Biomarker for the Treatment of Human Diseases

Human growth and development are tightly regulated processes that involve the interplay of numerous signaling pathways. One of these pathways is the histone pathway, which plays a critical role in the regulation of gene expression and chromosome stability. DNA damage has been linked to numerous diseases, including cancer, neurodegenerative disorders, and developmental delays. One of the key enzymes that try to prevent DNA damage is the histone acetyltransferase complex (HATs), which includes HDAC5 as one of its key components.

In recent years, the study of HDAC5 has revealed its potential as a drug target and biomarker for the treatment of various human diseases. HDAC5 has been shown to play a critical role in the development and progression of various diseases, including cancer, neurodegenerative disorders, and developmental delays. Its functions in these processes have led to its potential as a drug target, with several studies suggesting that inhibiting HDAC5 may be a promising strategy for the treatment of these diseases.

One of the key functions of HDAC5 is its role in the regulation of the chromatin structure. Chromatin is the complex of DNA, RNA, and proteins that make up the chromosomes. The chromatin structure plays a critical role in the regulation of gene expression, and HDAC5 is shown to play a key role in this process. Studies have shown that HDAC5 plays a critical role in the regulation of chromatin structure and that changes in this structure are associated with the development of various diseases.

In addition to its role in the regulation of chromatin structure, HDAC5 has also been shown to play a critical role in the regulation of cellular processes that are critical for the survival of cells. For example, HDAC5 has been shown to play a critical role in the regulation of cell apoptosis, which is the process by which cells die when they are no longer needed. Studies have shown that HDAC5 plays a critical role in the regulation of cell apoptosis and that changes in this process are associated with the development of various diseases, including cancer.

Another function of HDAC5 is its role in the regulation of the DNA damage response. DNA damage has been shown to play a critical role in the development and progression of various diseases, including cancer. The DNA damage response is a series of cellular processes that occur when DNA is damaged or mutated. HDAC5 is shown to play a critical role in the regulation of the DNA damage response and that changes in this process are associated with the development of various diseases.

In conclusion, HDAC5 is a promising drug target and biomarker for the treatment of various human diseases. Its functions in the regulation of the chromatin structure, cellular processes, and the DNA damage response have led to its potential as a therapy for a wide range of diseases. Further research is needed to fully understand the mechanisms of HDAC5's role in these processes and to develop effective treatments for the various diseases that are associated with its dysfunction.

Protein Name: Histone Deacetylase 5

Functions: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Serves as a corepressor of RARA and causes its deacetylation (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758)

The "HDAC5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about HDAC5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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