HDAC7: A Potential Drug Target for Many Diseases (G51564)

Target Name: HDAC7

NCBI ID: G51564

HDAC7

HDAC7: A Potential Drug Target for Many Diseases

Histone deacetylase 7 (HDAC7), also known as HDAC7A or hDAC7, is a protein that plays a critical role in the regulation of gene expression and DNA replication in the nucleus of the cell. It is a member of the HDAC family of enzymes, which also includes HDACs 1-6 and 9, and is responsible for the deacetylation of histones, which are small proteins that play a structural role in organizing DNA in the nucleus.

HDAC7 is widely expressed in various tissues and cells, including the brain, pancreas, and gastrointestinal tract, and is involved in the regulation of a wide range of cellular processes, including cell growth, differentiation, and reproduction. It is also involved in the development and progression of many diseases, including cancer.

Due to its involvement in multiple cellular processes, HDAC7 has been identified as a potential drug target or biomarker for a variety of diseases. One of the main reasons for this is that HDAC7 is a good candidate for drugs that can inhibit its activity, as this can have a wide range of effects on cellular processes that are affected by HDAC7.

One of the main advantages of HDAC7 as a drug target is its high degree of specificity. HDAC7 is a protein that is expressed in most tissues and cells, but its levels are much lower in tissues that are affected by the disease. This allows for drugs that specifically target HDAC7 to be effective in treating a wide range of diseases.

Another advantage of HDAC7 is its ability to act as a negative regulator. HDAC7 can bind to specific DNA sequences and prevent them from being repressed, which can lead to the activation of gene expression. This allows HDAC7 to play a role in the development and progression of diseases, as changes in the expression of genes can contribute to the development of disease.

HDAC7 is also involved in the regulation of cellular processes that are important for the development and progression of cancer. For example, HDAC7 has been shown to play a role in the regulation of the replication of cancer cells, and it has been shown to promote the development of cancer by inhibiting the apoptosis (programmed cell death) of cancer cells.

In addition to its role in the regulation of cancer development, HDAC7 is also involved in the regulation of many other cellular processes that are important for overall cellular health. For example, HDAC7 has been shown to play a role in the regulation of cell migration, and it has been shown to contribute to the development of many diseases, including cancer.

Despite its involvement in a wide range of cellular processes, HDAC7 is relatively well understood, and there is much that is still to be learned about its role in the regulation of these processes. This is why it is an attractive target for drug development, as researchers can use a variety of techniques, including genetic and biochemical studies, to gain a better understanding of its function.

In conclusion, HDAC7 is a protein that plays a critical role in the regulation of gene expression and DNA replication in the nucleus of the cell. It is a member of the HDAC family of enzymes and is involved in the regulation of a wide range of cellular processes, including cell growth, differentiation, and reproduction. Its high degree of specificity and its ability to act as a negative regulator make it an attractive target for drug development, and its involvement in the regulation of many cellular processes that are important for overall cellular health makes it a valuable biomarker for a variety of diseases.

Protein Name: Histone Deacetylase 7

Functions: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565). Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758)

The "HDAC7 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about HDAC7 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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