DROSHA: A Protein Involved in Cell Signaling Pathways and Disease Development

Target Name: DROSHA

NCBI ID: G29102

DROSHA

DROSHA: A Protein Involved in Cell Signaling Pathways and Disease Development

DROSHA (Drosha ribonuclease III, transcript variant 2) is a protein that is expressed in various cell types of the human body, including muscle, liver, and kidney cells. It is a member of the nucleotide-binding oligomerase (NBO) family, which is responsible for the hydrolysis of DNA-protein bonds.

DROSHA is expressed in the cytoplasm of all cell types and is involved in the regulation of gene expression. It has been shown to play a role in the development and progression of various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

One of the key functions of DROSHA is its ability to interact with the protein p21 (T-cell antigen recognition receptor) and the transcription factor p53. These proteins are involved in the regulation of cell growth, apoptosis, and DNA damage repair, respectively . By interacting with these proteins, DROSHA can influence the expression of genes that are necessary for cell survival and growth.

DROSHA has also been shown to play a role in the regulation of cellular signaling pathways. It has been shown to interact with the protein kinase A尾1 (K-A尾1), which is involved in the regulation of neurodegenerative diseases. The interaction between DROSHA and A尾1 has been shown to contribute to the development of neurotoxicity in various models of neurodegenerative disease.

In addition to its role in cellular signaling pathways, DROSHA has also been shown to be involved in the regulation of gene expression and DNA replication. It has been shown to interact with the protein DNAT-II (DnaTrap-interactive protein II), which is involved in the regulation of DNA replication. This interaction has been shown to contribute to the development of genetic mutations in various organisms.

DROSHA has also been shown to play a role in the regulation of cellular transport. It has been shown to interact with the protein TRF2 (Tripartite regulatory factor 2), which is involved in the regulation of intracellular protein transport. This interaction has been shown to contribute to the regulation of cellular processes, including the transport of various proteins to their respective intracellular locations.

In conclusion, DROSHA is a protein that has been shown to play a role in the regulation of various cellular processes in the human body. Its functions in cell signaling pathways, gene expression, DNA replication, and cellular transport have been described in various studies. Given its involvement in the development and progression of various diseases, DROSHA is a potential drug target or biomarker for a variety of therapeutic approaches. Further research is needed to fully understand the role of DROSHA in human health and disease.

Protein Name: Drosha Ribonuclease III

Functions: Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies

The "DROSHA Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about DROSHA comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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