Sulfotransferase 1C3: A Critical Enzyme for Toxin and Drug Detoxification

Target Name: SULT1C3

NCBI ID: G442038

SULT1C3

Sulfotransferase 1C3: A Critical Enzyme for Toxin and Drug Detoxification

Sulfotransferase 1C3 (ISOform 2), also known as SULT1C3, is a protein that is expressed in various tissues throughout the body. It plays a crucial role in the detoxification of harmful substances that have been introduced into the body. Sulfotransferase 1C3 is a member of the Sulfotransferase family, which includes four isoforms: SULT1C1, SULT1C2, SULT1C3, and SULT1C4.

Sulfotransferase 1C3 is a 21-kDa protein that is expressed in the liver, kidneys, heart, and other tissues. It is primarily localized to the cytoplasm of the cells, where it is involved in the detoxification of a wide variety of harmful substances, including drugs, toxins, and other harmful substances that have been introduced into the body.

One of the primary functions of sulfotransferase 1C3 is to facilitate the detoxification of drugs. Many drugs are metabolized by the liver and then excreted in the urine. However, some drugs can be metabolized by other tissues in the body, such as the kidneys, and then excreted in the urine. Sulfotransferase 1C3 plays a critical role in the detoxification of these drugs by helping to transfer the metabolites to the cytoplasm, where they can be eliminated from the body.

In addition to its role in drug detoxification, sulfotransferase 1C3 is also involved in the detoxification of other substances that are harmful to the body, such as toxins and other substances that have been introduced into the body through various means, such as food, water, or air.

Sulfotransferase 1C3 is also involved in the regulation of cellular signaling pathways. It is a key enzyme in the detoxification of xenobiotics, which are drugs or other substances that are toxic to the body. Xenobiotics can cause damage to the cells and contribute to the development of various diseases, including cancer. Sulfotransferase 1C3 helps to protect the cells by facilitate the detoxification of xenobiotics and by regulating the signaling pathways that are involved in the detoxification process.

Sulfotransferase 1C3 is also involved in the regulation of cellular signaling pathways related to inflammation. It is a key enzyme in the detoxification of inflammatory cytokines, which are proteins that are involved in the regulation of cellular signaling pathways that contribute to inflammation. Sulfotransferase 1C3 helps to protect the cells by facilitating the detoxification of inflammatory cytokines and by regulating the signaling pathways that are involved in inflammation.

Sulfotransferase 1C3 is also involved in the regulation of cellular signaling pathways related to cell death. It is a key enzyme in the detoxification of cell-mediated stress, which is the damage that occurs to cells as a result of various signaling pathways being activated inside the cells. Sulfotransferase 1C3 helps to protect the cells by facilitating the detoxification of cell-mediated stress and by regulating the signaling pathways that are involved in cell death.

In conclusion, sulfotransferase 1C3 is a critical enzyme that plays a crucial role in the detoxification of harmful substances that have been introduced into the body. It is expressed in various tissues throughout the body and is primarily localized to the cytoplasm of the cells. Sulfotransferase 1C3 is involved in the detoxification of drugs, toxins, and other harmful substances, as well as in the regulation of cellular signaling pathways

Protein Name: Sulfotransferase Family 1C Member 3

Functions: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor. Has sulfotransferase activity towards various substrates, such as bile acids, thyroid hormones and toward xenobiotic compounds such as chloro phenols and hydroxypyrenes. Lithocholic acid appears to be the best substrate among the endogenous compounds tested and 3,3',5,5'-tetrachloro-4,4'-biphenyldiol shows the highest specific activity among the xenobiotic compounds

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