SULT1A1: A Potential Drug Target and Biomarker for liver disease

Target Name: SULT1A1

NCBI ID: G6817

SULT1A1

SULT1A1: A Potential Drug Target and Biomarker for liver disease

SULT1A1, also known as aryl sulfotransferase 1, is a gene that encodes a protein located in the liver. The liver is a crucial organ that plays a vital role in the metabolism of numerous drugs, including many drugs used to treat a wide range of diseases . As such, identifying potential drug targets and biomarkers for liver diseases is an important area of 鈥嬧?媟esearch. One promising candidate for drug targeting and biomarker development is SULT1A1.

SULT1A1 is a member of the superfamily of cysteine 鈥嬧?媝roteases, which are a group of enzymes that play a critical role in the breakdown of proteins. These enzymes are involved in a wide range of physiological processes in the body, including the regulation of cell growth, differentiation, and survival. SULT1A1 is specifically involved in the detoxification of aryl compounds, which are often found in environmental and occupational exposures.

SULT1A1 has been identified as a potential drug target for a variety of liver diseases. One reason for its potential as a drug target is its location in the liver, which is the primary site of metabolism for many drugs. Additionally, SULT1A1 has been shown to be involved in the metabolism of a wide range of drugs, including many anti-cancer drugs, making it an attractive target for drug developers.

In addition to its potential as a drug target, SULT1A1 has also been identified as a potential biomarker for a variety of liver diseases. One reason for its potential as a biomarker is its expression in the liver, which makes it a reliable indicator of liver function . Additionally, SULT1A1 has been shown to be involved in the regulation of cell growth and differentiation, which could make it an attractive biomarker for diseases such as liver cancer, fibrosis, and biliary tract cancer.

SULT1A1 has also been shown to be involved in the regulation of inflammation, which could make it an attractive biomarker for a variety of liver diseases. One reason for its involvement in inflammation is its role in the production of reactive oxygen species (ROS), which can contribute to the development of oxidative stress and inflammation in the liver.

In conclusion, SULT1A1 is a promising candidate for drug targeting and biomarker development for a variety of liver diseases. Further research is needed to fully understand its role in these processes and to develop safe and effective drugs and biomarkers for its targeting. By doing so, we can potentially improve treatment outcomes for a wide range of liver diseases.

Protein Name: Sulfotransferase Family 1A Member 1

Functions: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a wide variety of acceptor molecules bearing a hydroxyl or an amine groupe. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Displays broad substrate specificity for small phenolic compounds. Plays an important role in the sulfonation of endogenous molecules such as steroid hormones and 3,3'-diiodothyronin (PubMed:16221673, PubMed:12471039, PubMed:22069470, PubMed:21723874, PubMed:10199779, PubMed:7834621). Mediates the sulfate conjugation of a variety of xenobiotics, including the drugs acetaminophen and minoxidil (By similarity). Mediates also the metabolic activation of carcinogenic N-hydroxyarylamines leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (PubMed:7834621). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system

The "SULT1A1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SULT1A1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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