Sulfotransferase 1A2: A Protein Involved in Cell Signaling Pathways and Detoxification

Target Name: SULT1A2

NCBI ID: G6799

SULT1A2

Sulfotransferase 1A2: A Protein Involved in Cell Signaling Pathways and Detoxification

Sulfotransferase 1A2 (SULT1A2) is a protein that is expressed in various tissues throughout the body, including the liver, heart, and kidneys. It plays a critical role in the regulation of cell signaling pathways, and is involved in the detoxification of harmful substances that have been produced by cellular processes.

SULT1A2 is a member of the superfamily of cysteine proteinases, which are a group of enzymes that are characterized by the presence of a cysteine residue that can undergo a chemical reaction known as cysteine substitution. This reaction is often associated with the production of reactive oxygen species (ROS), which can cause damage to cellular components and contribute to a variety of cellular and physiological processes.

SULT1A2 is widely expressed in many different tissues and is involved in a variety of physiological processes. In the liver, it is involved in the detoxification of a variety of compounds, including drugs and other harmful substances that have been produced by cellular processes. In the heart, it is involved in the regulation of contractility and in the production of adenosine, a hormone that helps to relax smooth muscle and improve blood flow. In the kidneys, it is involved in the regulation of water and electrolyte balance.

SULT1A2 is also involved in the detoxification of ROS, which are highly reactive molecules that can cause damage to cellular components and contribute to a variety of cellular and physiological processes. ROS can be produced by cellular processes, as well as by exposure to environmental toxins, and they can damage cellular components by creating reactive oxygen species (ROS) that can interact with other molecules in the cell. SULT1A2 is involved in the detoxification of ROS by producing cysteine, which can then undergo a chemical reaction to form sulfuric acid, which is then excreted from the body.

SULT1A2 is also involved in the regulation of cellular signaling pathways. Many signaling pathways involve the production of ROS, which can interact with other molecules in the cell to regulate a wide range of cellular processes. SULT1A2 is involved in the regulation of these pathways by producing cysteine, which can then be used to form a reactive sulfur species that can interact with other molecules in the cell. This interaction between cysteine and ROS is critical for the regulation of cellular signaling pathways and is a potential drug target for SULT1A2.

In conclusion, Sulfotransferase 1A2 (SULT1A2) is a protein that is widely expressed in various tissues throughout the body and plays a critical role in the regulation of cell signaling pathways. It is involved in the detoxification of harmful substances that have been produced by cellular processes, as well as in the production of reactive oxygen species that can cause damage to cellular components. SULT1A2 is a potential drug target for the regulation of cellular signaling pathways and may have a variety of therapeutic applications in a variety of diseases.

Protein Name: Sulfotransferase Family 1A Member 2

Functions: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfonation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   expression level;
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•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
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