SULT1B1: A Potential Drug Target for Cell Metabolism and Signaling

Target Name: SULT1B1

NCBI ID: G27284

SULT1B1

SULT1B1: A Potential Drug Target for Cell Metabolism and Signaling

Sulfotransferase 1B1 (SULT1B1) is a gene that encodes a protein located in the endoplasmic reticulum (ER) of cells. The ER is a membrane-wrapped structure responsible for synthesizing and modifying proteins and transporting them to the cell membrane surface for secretion or endocytosis effect. The protein encoded by the SULT1B1 gene is a sulfur transferase, which is responsible for the transfer reaction of sulfur in cells. Sulfur has important biological functions in organisms, such as participating in processes such as energy metabolism and cell signaling. Therefore, it is of important biological significance to study the role of SULT1B1 in cell metabolism and signaling.

In recent years, with the development of gene sequencing technology, researchers have conducted in-depth studies on the function of the SULT1B1 gene. Many studies have shown that SULT1B1 plays an important role in cell metabolism and signaling. For example, studies have shown that SULT1B1 participates in the glucose metabolism process in cells, providing energy for cell metabolism by catalyzing the conversion of glucose-6-phosphate into glucose-6-phosphate. In addition, SULT1B1 is also involved in the synthesis and modification of intracellular lipids, providing necessary components for the construction of cell membranes.

In addition, SULT1B1 also plays an important role in cell signaling. Studies have shown that SULT1B1 participates in multiple signaling pathways in cells, such as the G-protein coupled receptor (GPCR) signaling pathway. Through the GPCR signaling pathway, SULT1B1 is responsible for modifying GPCR receptors in cells, thereby affecting intracellular signal transmission. In addition, SULT1B1 is also involved in the regulation of multiple signaling pathways in cells, such as cell cycle regulation, apoptosis regulation, etc.

SULT1B1's role in cell metabolism and signaling makes it a potential drug target. Currently, researchers are conducting in-depth studies on the application prospects of SULT1B1 in drug development. For example, some studies have shown that inhibiting the activity of SULT1B1 can slow down cell aging and thereby extend cell life. In addition, SULT1B1 is also involved in the clearance process of intracellular metabolites. Therefore, inhibiting the activity of SULT1B1 may be helpful in the treatment of certain metabolic diseases.

In addition, SULT1B1 also plays an important role in tumorigenesis. Studies have shown that the expression level of SULT1B1 is closely related to the incidence and prognosis of various tumors. For example, studies have shown that the expression level of SULT1B1 is positively correlated with the incidence and prognosis of breast cancer, and negatively correlated with the incidence and prognosis of cervical cancer. Therefore, studying the role of SULT1B1 in tumorigenesis will help develop new tumor treatment strategies.

In summary, SULT1B1 plays an important role in cell metabolism and signaling and has become a potential drug target. Through in-depth study of the application prospects of SULT1B1 in drug research and development, new ideas and methods can be provided for the treatment of various metabolic diseases and tumors.

Protein Name: Sulfotransferase Family 1B Member 1

Functions: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine (T3) and reverse triiodothyronine (rT3) (PubMed:28084139, PubMed:9443824, PubMed:9463486). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system (PubMed:35165440)

The "SULT1B1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SULT1B1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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