KCNA5: A Protein Implicated in Cardiac Arrhythmias (G3741)

Target Name: KCNA5

NCBI ID: G3741

KCNA5

KCNA5: A Protein Implicated in Cardiac Arrhythmias

KCNA5 is a protein that is expressed in the heart and is involved in the regulation of electrical activity in the heart. It is a member of the cardiac potassium channel (IKs) family, which are responsible for the regulation of the flow of electrical signals through the heart. Mutations in the KCNA5 gene have been linked to various cardiac arrhythmias, including sudden cardiac death (SCD) in humans.

The drug target potential of KCNA5 is an attractive proposition due to its involvement in cardiac arrhythmias. It is a potential drug target for treating a range of cardiac arrhythmias, including SCD, and has been shown to be involved in the pathophysiology of various cardiac conditions, including heart failure, hypertension, and hypokalemia (low potassium levels).

KCNA5 function and structure

KCNA5 is a 120 amino acid protein that is expressed in the heart and is predominantly localized to the cardiac muscle. It is a member of theIKs family and is responsible for the regulation of the heart's electrical activity. It plays a critical role in maintaining the normal heart rhythm by controlling the flow of electrical signals through the heart.

The structure of KCNA5 has been determined through biochemical and biophysical studies. It has a unique open framework with a distinct N-terminus, a catalytic C-terminus, and a transmembrane region. The transmembrane region is composed of four beta-helices, each of which is composed of two alpha-helices. The beta-helices are held together by hydrogen bonds and form a well- conserved motif that is characteristic of theIKs family.

KCNA5 functions as a regulatory protein for cardiac potassium channels

KCNA5 is involved in the regulation of the heart's electrical activity by controlling the flow of electrical signals through the cardiac potassium channels (IKs). These channels are responsible for the rapid and efficient flow of electrical signals through the heart, which is essential for maintaining the normal heart rhythm.

KCNA5 functions as a positive regulator of theIKs channels. It increases the activity of these channels by increasing the number of open channels and by decreasing the activity of the channels that are already open. This increase in activity allows the heart to generate a stronger electrical signal, which is essential for proper heart function.

KCNA5 is also involved in the regulation of the heart's electrical activity by controlling the intracellular signaling pathways that are responsible for the regulation of these channels. It does this by interacting with several intracellular signaling pathways, including the protein Ser (serine) and the protein tyrosine kinase (TK).

KCNA5 is also involved in the regulation of the heart's electrical activity by controlling the ion channels that are responsible for the rapid and efficient flow of electrical signals through the heart. These channels are composed of a combination of sodium (Na+), potassium (K+), and calcium (Ca2+) channels. KCNA5 functions as a positive regulator of these channels by increasing the activity of the channels that are already open and by decreasing the activity of the channels that are already closed.

KCNA5 is also involved in the regulation of the heart's electrical activity by controlling the levels of intracellular potassium ions (K+) and sodium ions (Na+). This is achieved by the regulation of the channels that are responsible for the rapid and efficient flow of electrical signals through the heart.

Mutations in the KCNA5 gene have been linked to various cardiac arrhythmias, including SCD. These mutations have been shown to alter the function of the cardiac potassium channels, leading to abnormal electrical activity and potentially leading to cardiac arrhythmias.

Drug targeting potential

KCNA5 is a potential drug target for treating a range of cardiac arrhythmias, including SCD. The regulation of

Protein Name: Potassium Voltage-gated Channel Subfamily A Member 5

Functions: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:12130714). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (PubMed:12130714). Homotetrameric channels display rapid activation and slow inactivation (PubMed:8505626, PubMed:12130714). May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation (PubMed:11524461)

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